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Gene Review

CRIPT  -  cysteine-rich PDZ-binding protein

Homo sapiens

Synonyms: Cysteine-rich PDZ-binding protein, Cysteine-rich interactor of PDZ three, Cysteine-rich interactor of PDZ3, HSPC139, SSMDF
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High impact information on CRIPT

  • CRIPT is a postsynaptic protein that binds selectively to the third PDZ domain (PDZ3) of PSD-95 [1].
  • Here we show that CRIPT also binds directly to microtubules, thereby linking PSD-95 to the microtubule cytoskeleton [1].
  • The structural features of the PDZ domains with the C-termini of different receptors (GluR6), channels (Kv1.4), and cytoskeletal proteins (CRIPT) provide insight into targeting these regions [2].

Anatomical context of CRIPT


  1. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Passafaro, M., Sala, C., Niethammer, M., Sheng, M. Nat. Neurosci. (1999) [Pubmed]
  2. Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels. Piserchio, A., Spaller, M., Mierke, D.F. The AAPS journal [electronic resource]. (2006) [Pubmed]
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