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Gene Review

apt  -  adenine phosphoribosyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0463, JW0458
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Disease relevance of apt


High impact information on apt

  • MTAN is therefore involved in quorum sensing, recycling MTA from the polyamine pathway via adenine phosphoribosyltransferase and recycling MTR to methionine [2].
  • The difference in the repair phenotype of CPD between the HPRT gene and the APRT gene coincides with differences between both genes with regard to the DNA strand distribution of previously published UV-induced mutations [3].
  • Data are presented indicating that adenine may be transported without participation of adenine phosphoribosyltransferase [4].
  • In two mutants with undetected adenine phosphoribosyltransferase, the rate of adenine uptake was about 30% of that in their parent strain, and evidence was obtained to confirm that adenine had then been utilized via purine nucleoside phosphorylase [5].
  • An open reading frame immediately downstream of fnrA encoded adenine phosphoribosyltransferase (EC [6].


  1. Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes. Hershey, H.V., Taylor, M.W. Gene (1986) [Pubmed]
  2. Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. Singh, V., Evans, G.B., Lenz, D.H., Mason, J.M., Clinch, K., Mee, S., Painter, G.F., Tyler, P.C., Furneaux, R.H., Lee, J.E., Howell, P.L., Schramm, V.L. J. Biol. Chem. (2005) [Pubmed]
  3. Analysis of repair of cyclobutane pyrimidine dimers and pyrimidine 6-4 pyrimidone photoproducts in transcriptionally active and inactive genes in Chinese hamster cells. Vreeswijk, M.P., van Hoffen, A., Westland, B.E., Vrieling, H., van Zeeland, A.A., Mullenders, L.H. J. Biol. Chem. (1994) [Pubmed]
  4. Transport of purines and deoxyadenosine in Escherichia coli. Roy-Burman, S., Visser, D.W. J. Biol. Chem. (1975) [Pubmed]
  5. Transport of adenine, hypoxanthine and uracil into Escherichia coli. Burton, K. Biochem. J. (1977) [Pubmed]
  6. Anaerobic control of denitrification in Pseudomonas stutzeri escapes mutagenesis of an fnr-like gene. Cuypers, H., Zumft, W.G. J. Bacteriol. (1993) [Pubmed]
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