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Gene Review:

miaB - tRNA-i(6)A37 methylthiotransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0653, JW0658, yleA

Pierrel, F. et al., Pierrel, F. et al.

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Disease relevance of miaB

Finally, the expression of MiaBTm from T. maritima in an E. coli mutant strain lacking functional miaB gene allowed production of ms2i6A-37 [1].

High impact information on miaB

The product of the miaB gene, MiaB, from Escherichia coli participates in the methylthiolation of the adenosine 37 residue during modification of tRNAs that read codons beginning with uridine [2].

References

MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase. Pierrel, F., Hernandez, H.L., Johnson, M.K., Fontecave, M., Atta, M. J. Biol. Chem. (2003) [Pubmed]
Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein. Pierrel, F., Björk, G.R., Fontecave, M., Atta, M. J. Biol. Chem. (2002) [Pubmed]

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