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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cobB  -  deacetylase of acs and cheY, chemotaxis...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1106, JW1106, npdA, ycfY
 
 
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Disease relevance of cobB

 

High impact information on cobB

  • Recombinant E. coli cobT and cobB proteins each showed a weak NAD-dependent mono-ADP-ribosyltransferase activity using 5, 6-dimethylbenzimidazole as a substrate [2].
 

Analytical, diagnostic and therapeutic context of cobB

  • Isothermal titration calorimetry studies were used to compare the affinity of cobB for a variety of cognate and non-cognate acetyl-lysine-bearing peptides revealing an exothermic reaction with relatively little discrimination between substrates [1].

References

  1. Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli. Zhao, K., Chai, X., Marmorstein, R. J. Mol. Biol. (2004) [Pubmed]
  2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Frye, R.A. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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