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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lepB  -  leader peptidase (signal peptidase I)

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2566, JW2552, lep
 
 
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High impact information on lepB

  • The transcription of lspA, lgt (encoding prolipoprotein transferase), and lepB (encoding type I signal peptidase), monitored by real-time quantitative reverse transcription-PCR, reveals a differential expression pattern during various stages of rickettsial intracellular growth [1].
  • By contrast, non-cleaved holocytochrome c containing covalently bound heme accumulated in the membranes of a lepB mutant, which indicated that signal sequence cleavage and heme attachment are independent steps in the cytochrome c maturation pathway [2].

References

  1. The lspA Gene, Encoding the Type II Signal Peptidase of Rickettsia typhi: Transcriptional and Functional Analysis. Rahman, M.S., Ceraul, S.M., Dreher-Lesnick, S.M., Beier, M.S., Azad, A.F. J. Bacteriol. (2007) [Pubmed]
  2. Translocation to the periplasm and signal sequence cleavage of preapocytochrome c depend on sec and lep, but not on the ccm gene products. Thöny-Meyer, L., Künzler, P. Eur. J. Biochem. (1997) [Pubmed]
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