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Gene Review

gadW  -  transcriptional activator of gadA and...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3499, JW3483, yhiW
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High impact information on gadW

  • The gadX gene and a second downstream araC-like transcription factor gene, gadW, were mutated separately and in combination, and the gene expression profiles of the mutants were compared to those of the wild-type strain grown in neutral and acidified media under conditions favoring induction of glutamate-dependent acid resistance [1].

Other interactions of gadW

  • The control loop involves the GadX protein repressing the expression of gadW and the GadW protein repressing or inhibiting RpoS, which is the alternative sigma factor that drives transcription of gadX [2].


  1. Genes of the GadX-GadW regulon in Escherichia coli. Tucker, D.L., Tucker, N., Ma, Z., Foster, J.W., Miranda, R.L., Cohen, P.S., Conway, T. J. Bacteriol. (2003) [Pubmed]
  2. pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistance. Ma, Z., Richard, H., Foster, J.W. J. Bacteriol. (2003) [Pubmed]
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