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Gene Review:

bax - putative glucosaminidase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3559, JW5653

Ishibashi, Y. et al., Schneider, E. et al., Zhang, H. et al.

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Disease relevance of bax

A truncated bax gene (Bax112-192) containing the region lethal to E. coli was then introduced into a murine promyeloid cell line, FDC-P1 [1].

High impact information on bax

At the position 219 base pairs upstream of malS, we found a divergently transcribed gene, bax, which has been recognized previously [2].
Human bcl-2 family of genes including bcl-2, bcl-x-l, bcl-x-s, and bax has been shown to be functionally involved in apoptosis [3].

References

Pore formation domain of human pro-apoptotic Bax induces mammalian apoptosis as well as bacterial death without antagonizing anti-apoptotic factors. Ishibashi, Y., Nishimaki, K., Asoh, S., Nanbu-Wakao, R., Yamada, T., Ohta, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Molecular characterization of the MalT-dependent periplasmic alpha-amylase of Escherichia coli encoded by malS. Schneider, E., Freundlieb, S., Tapio, S., Boos, W. J. Biol. Chem. (1992) [Pubmed]
Combinatorial interaction of human bcl-2 related proteins: mapping of regions important for bcl-2/bcl-x-s interaction. Zhang, H., Saeed, B., Ng, S.C. Biochem. Biophys. Res. Commun. (1995) [Pubmed]

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