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Gene Review

rplL  -  50S ribosomal subunit protein L7/L12

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3977, JW3949
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Disease relevance of rplL


High impact information on rplL

  • These mutant plasmids exhibit normal transcription of rplJ-rplL but do not translate rplJ messenger RNA to yield plasmid-specified L10 ribosomal protein [2].
  • The rplL564 mutation suppresses the temperature sensitive phenotype and the increased translational misreading associated with the prfA1 allele, while other studied rplL mutant alleles do not [3].
  • Evidence that Rho and NusA are involved in termination in the rplL-rpoB intercistronic region [4].

Biological context of rplL

  • One of these plasmids has been used to isolate nine variants having mutations that lie in a putative internal promoter which is located between rplL and rpoB [5].

Other interactions of rplL

  • A high copy number plasmid that carries the promoter PJ, intact rplJ and a deletion of the 3' terminal portion of rplL is detrimental to the growth of the host bacterium [2].


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