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Gene Review:

rplL - 50S ribosomal subunit protein L7/L12

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3977, JW3949

Fiil, N.P. et al., Kirsebom, L.A. et al., Zhang, S. et al., An, G. et al., Ralling, G. et al.

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Disease relevance of rplL

The amino acid sequences of mutationally altered ribosomal protein L7/L12 from four different rplL mutants of Escherichia coli were determined and correlated with some features of the mutant ribosomes [1].

High impact information on rplL

These mutant plasmids exhibit normal transcription of rplJ-rplL but do not translate rplJ messenger RNA to yield plasmid-specified L10 ribosomal protein [2].
The rplL564 mutation suppresses the temperature sensitive phenotype and the increased translational misreading associated with the prfA1 allele, while other studied rplL mutant alleles do not [3].
Evidence that Rho and NusA are involved in termination in the rplL-rpoB intercistronic region [4].

Biological context of rplL

One of these plasmids has been used to isolate nine variants having mutations that lie in a putative internal promoter which is located between rplL and rpoB [5].

Other interactions of rplL

A high copy number plasmid that carries the promoter PJ, intact rplJ and a deletion of the 3' terminal portion of rplL is detrimental to the growth of the host bacterium [2].

References

Primary structures of mutationally altered ribosomal protein L7/L12 and their effects on cellular growth and translational accuracy. Kirsebom, L.A., Amons, R., Isaksson, L.A. Eur. J. Biochem. (1986) [Pubmed]
Post-transcriptional regulatory mutants in a ribosomal protein-RNA polymerase operon of E. coli. Fiil, N.P., Friesen, J.D., Downing, W.L., Dennis, P.P. Cell (1980) [Pubmed]
Genetic implication for an interaction between release factor one and ribosomal protein L7/L12 in vivo. Zhang, S., Rydén-Aulin, M., Kirsebom, L.A., Isaksson, L.A. J. Mol. Biol. (1994) [Pubmed]
Evidence that Rho and NusA are involved in termination in the rplL-rpoB intercistronic region. Ralling, G., Linn, T. J. Bacteriol. (1987) [Pubmed]
Characterization of promoter-cloning plasmids: analysis of operon structure in the rif region of Escherichia coli and isolation of an enhanced internal promoter mutant. An, G., Friesen, J.D. J. Bacteriol. (1980) [Pubmed]

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