Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

hflK - modulator for HflB protease specific for...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4170, JW4132, hflA, hslY

Noble, J.A. et al., Banuett, F. et al., Kihara, A. et al.

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High impact information on hflK

We have determined the nucleotide sequence of 3843 base pairs containing hflA and have found three large open reading frames corresponding to hflX, hflK, and hflC [1].
We have used the operon fusion to infer the direction of transcription of the hflK gene--toward hflC and in the same direction as hflC [2].

Biological context of hflK

Interestingly, the inhibitory action of YccA11 was mediated by HflKC, since the deletion of hflK-hflC suppressed the yccA11 phenotype [3].

References

The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain. Noble, J.A., Innis, M.A., Koonin, E.V., Rudd, K.E., Banuett, F., Herskowitz, I. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Identification of polypeptides encoded by an Escherichia coli locus (hflA) that governs the lysis-lysogeny decision of bacteriophage lambda. Banuett, F., Herskowitz, I. J. Bacteriol. (1987) [Pubmed]
Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA. Kihara, A., Akiyama, Y., Ito, K. J. Mol. Biol. (1998) [Pubmed]

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