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Gene Review

lysS  -  lysyl-tRNA synthetase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of lysS

  • Lysyl-tRNA synthetases are synthesized in Escherichia coli from two distinct genes, lysS and lysU, which are regulated differentially [1].
  • However, the capacity of tRNA(3)(Lys) to interact with lysyl-tRNA synthetase does not entirely explain the enhanced preference for selection of tRNA(3)(Lys) for the replication of HIV-1 [2].

High impact information on lysS

  • Loss of this base pair reduces mischarging by the E. coli lysyl-tRNA synthetase [3].
  • Here, we show that the N-terminal domains of three E. coli multidomain proteins such as lysyl-tRNA synthetase, threonyl-tRNA synthetase, and aconitase are potent solubility enhancers for various C-terminal heterologous proteins [4].


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