Gene Review:
argR - arginine repressor ArgR
Escherichia coli O157:H7 str. EDL933
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Disease relevance of argR
- In this study we analyzed 537 E. coli strains and show that the argR allele in E. coli B, which causes deregulation, is rare in isolates obtained from natural sources [1].
High impact information on argR
- A single nucleotide polymorphism between Escherichia coli strains K12 and B is known to alter the mechanism by which the arginine repressor regulates arginine biosynthesis, from a regulated system in E. coli K12 to a deregulated system in E. coli B [1].
Analytical, diagnostic and therapeutic context of argR
- Moreover, sequence analysis of 85 strains shows no evidence of selection at the arginine repressor locus [1].
References
- The argRB of Escherichia coli is rare in isolates obtained from natural sources. Merlo, L.M., Sadowsky, M.J., Ferguson, J.A., Dean, A.M. Gene (2006) [Pubmed]
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