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Gene Review:

VPRBP - Vpr (HIV-1) binding protein

Homo sapiens

Synonyms: DCAF1, DDB1-and CUL4-associated factor 1, HIV-1 Vpr-binding protein, KIAA0800, MGC102804, ...

Zhao, L.J. et al., Zhao, L.J. et al.

Zhao, Jian, Zhu, Zhao, Zhang, Chinnadurai,

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Disease relevance of VPRBP

As an examination of this approach, we have prepared an adenoviral vector capable of expressing siRNA molecules targeting p53 or VprBP/KIAA0800, a cellular protein that interacts with the HIV auxiliary protein Vpr [1].

High impact information on VPRBP

Sox9 transactivation of the KIAA0800 promoter appears to be exerted mainly through the relief of promoter repression [2].

Analytical, diagnostic and therapeutic context of VPRBP

Further, our recent sequence analysis shows that KIAA0800 protein is 97% identical between human and mouse [2].

References

Specific gene inhibition by adenovirus-mediated expression of small interfering RNA. Zhao, L.J., Jian, H., Zhu, H. Gene (2003) [Pubmed]
Sox9 transactivation and testicular expression of a novel human gene, KIAA0800. Zhao, L.J., Zhang, S., Chinnadurai, G. J. Cell. Biochem. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP012134	Anopheles gambiae str. PEST
VPRBP	Bos taurus
dcaf-1	Caenorhabditis elegans
VPRBP	Canis lupus familiaris
mahj	Drosophila melanogaster
VPRBP	Gallus gallus
Vprbp	Mus musculus
VPRBP	Pan troglodytes
Vprbp	Rattus norvegicus
vprbp	Xenopus (Silurana) tropicalis

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