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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

pfoR  -  regulatory protein

Clostridium perfringens str. 13

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Disease relevance of pfoR

  • Finally, we demonstrated that sloR, a S. pyogenes gene that closely resembles the Clostridium perfringens pfoR gene, exerts a negative effect on the expression of the slo gene [1].
  • Previous studies (T. Shimizu, A. Okabe, J. Minami, and H. Hayashi, Infect. Immun. 59:137-142, 1991) carried out with Escherichia coli suggested that the perfringolysin O structural gene, pfoA, was positively regulated by the product of the upstream pfoR gene [2].

High impact information on pfoR

  • These results indicate that pfoR positively controls expression of the pfoA gene [3].
  • The deduced amino acid sequence of pfoR possesses several motifs that are characteristic of DNA-binding proteins [3].
  • Nucleotide sequencing showed that this region contained one open reading frame (pfoR) coding for 343 amino acids [3].
  • In an attempt to confirm this hypothesis in C. perfringens, a pfoR-pfoA deletion mutant was complemented with isogenic pfoA(+) shuttle plasmids that varied only in their ability to encode an intact pfoR gene [2].


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