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Gene Review

Golga2  -  golgi autoantigen, golgin subfamily a, 2

Mus musculus

Synonyms: 130 kDa cis-Golgi matrix protein, AW555139, GM130, Golgin subfamily A member 2, mKIAA4150
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High impact information on Golga2

  • The transfection of either wild type (WT) or several mutant constructs (P448L, C318Y, L276I) into myotubes consistently showed clear co-localisation with GM130, a Golgi marker [1].
  • Moreover, we were successful in transfecting a dominant-negative ADP ribosylation factor 1 (ARF1) mutant, i.e., ARF1N126I, in myotubes, thus interfering with endoplasmic reticulum-Golgi traffic, as indicated by alterations of subcellular distribution of GM130, a cis/medial-Golgi marker [2].
  • On the other hand, expression of ARF1-N126I altered the subcellular localization of GM130, a cis -medial Golgi protein in skeletal-muscle fibres and myotubes, without interfering with CSHA1 targeting to either TC or developing SR [3].


  1. Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells. Dolatshad, N.F., Brockington, M., Torelli, S., Skordis, L., Wever, U., Wells, D.J., Muntoni, F., Brown, S.C. Exp. Cell Res. (2005) [Pubmed]
  2. Electrotransfer in differentiated myotubes: a novel, efficient procedure for functional gene transfer. Sandri, M., Bortoloso, E., Nori, A., Volpe, P. Exp. Cell Res. (2003) [Pubmed]
  3. Vesicle budding from endoplasmic reticulum is involved in calsequestrin routing to sarcoplasmic reticulum of skeletal muscles. Nori, A., Bortoloso, E., Frasson, F., Valle, G., Volpe, P. Biochem. J. (2004) [Pubmed]
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