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MeSH Review:

Ossification of Posterior Longitudinal Ligament

Yamada, K. et al., Koga, H. et al., Ho, E.K. et al., Koshizuka, Y. et al., Maroun, F.B. et al.

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Disease relevance of Ossification of Posterior Longitudinal Ligament

Cervical myelopathy consequent on ossification of posterior longitudinal ligament (OPLL) is very rare in Caucasians [1].

High impact information on Ossification of Posterior Longitudinal Ligament

This mutant exhibits ossification in various soft tissues, which is histologically similar to human OPLL (ossification of posterior longitudinal ligament of the spine) [2].
Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from the Japanese population [3].
Traumatic tetraparesis: a rare neurologic complication in ankylosing spondylitis with ossification of posterior longitudinal ligament of the cervical spine. A case report [4].

Chemical compound and disease context of Ossification of Posterior Longitudinal Ligament

STUDY DESIGN: This work was performed to investigate the role of vitamin K (VK) in the pathogenesis of ossification of posterior longitudinal ligament (OPLL), by analyzing the biochemical markers of the blood samples of OPLL patients and responses of ligament cells derived from OPLL lesion to VK2 [5].

References

Cervical myelopathy secondary to ossification of the posterior longitudinal ligament in a Caucasian patient. Maroun, F.B., Makino, A.P., Tong, T.R., Perkins, P.G., Arts, R., Jacob, J.C., Reddy, R. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1993) [Pubmed]
Isolation of novel mouse genes associated with ectopic ossification by differential display method using ttw, a mouse model for ectopic ossification. Koshizuka, Y., Ikegawa, S., Sano, M., Nakamura, K., Nakamura, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from the Japanese population. Koga, H., Hayashi, K., Taketomi, E., Matsunaga, S., Yashiki, S., Fujiyoshi, T., Sonoda, S., Sakou, T. Spine. (1996) [Pubmed]
Traumatic tetraparesis: a rare neurologic complication in ankylosing spondylitis with ossification of posterior longitudinal ligament of the cervical spine. A case report. Ho, E.K., Leong, J.C. Spine. (1987) [Pubmed]
High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament. Yamada, K., Inui, K., Iwamoto, M., Nakamura, H., Tsujio, T., Konishi, S., Ito, Y., Takaoka, K., Koike, T. Spine. (2003) [Pubmed]

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