Disease relevance of Platybasia

• Marfan's syndrome, ventricular septal defect and basilar impression in one patient [1].

High impact information on Platybasia

• Additionally, this girl developed hydrocephalus associated with platybasia and a Chiari 1 malformation [2].
• Transoral surgery was performed for irreducible anterior neuraxial compression at the craniovertebral junction caused by basilar impression, atlantoaxial subluxation with pseudotumor, or chordoma [3].
• Associated minor anomalies included fusion of the vertebral bodies of C5 and C6, cervical rib and platybasia [4].
• Cervicovertebral anomalies and basilar impression in Goldenhar syndrome [5].
• At admission, the MRI showed a basilar impression accompanied by Klippel-Feil syndrome of C4/5/6/7, but neurological symptoms of basilar impression were absent [6].

Gene context of Platybasia

• The symptoms of the basilar impression are probably caused by compression of the vessels of the lower cerebellar region and the brainstem as well as by disturbances of the CSF circulation [7].
• (3) The most appropriate operative procedure must be selected: stable platybasia with a nervous compression by Chiari is cured only by posterior decompression; odontoid instability is cured by reduction and posterior fixation, using hooks and autologous bone grafts on the posterior arches of C-1 and C-2 [8].
• Basilar impression associated with this case may be considered a pure coincidence, but rare cases of basilar impression and NF1 have been described [9].

References