Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Diarrhea Virus 2, Bovine Viral

Deregt, D. et al., Deregt, D. et al.

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Disease relevance of Diarrhea Virus 2, Bovine Viral

Alignment of E2 nucleotide sequences revealed that BVDV 2 are missing six nucleotides encoding the equivalent of amino acids 31 and 32 of BVDV 1 and thus, this difference can account for the BVDV 1-specificity of mAb 157 [1].

Biological context of Diarrhea Virus 2, Bovine Viral

Viruses of the BVDV 2 genotype are a cause of hemorrhagic and acute fatal disease in cattle in the US and Canada. In this study, monoclonal antibodies (mAbs) to the newly described BVDV 2 were produced after immunization with virus or a combination of virus and E2 peptide [2].

Gene context of Diarrhea Virus 2, Bovine Viral

From an original panel of 17 mAbs, 13 mAbs were identified as E2-specific by reactivity with a BVDV 2 recombinant E2 protein expressed in insect cells [2].

References

Mapping of a type 1-specific and a type-common epitope on the E2 (gp53) protein of bovine viral diarrhea virus with neutralization escape mutants. Deregt, D., Bolin, S.R., van den Hurk, J., Ridpath, J.F., Gilbert, S.A. Virus Res. (1998) [Pubmed]
Monoclonal antibodies to the E2 protein of a new genotype (type 2) of bovine viral diarrhea virus define three antigenic domains involved in neutralization. Deregt, D., van Rijn, P.A., Wiens, T.Y., van den Hurk, J. Virus Res. (1998) [Pubmed]

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