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High impact information on Huperzia

  • Several unique characters are observed in Huperzia, such as movement of the gene ndhF from the small single copy region into the inverted repeat [1].
  • Three new lycopodium alkaloids, 11alpha-hydroxyphlegmariurine B (2), 7alpha-hydroxyphlegmariurine B (3) and 7alpha,11alpha-dihydroxyphlegmariurine B (4) along with a known compound, phlegmariurine B (1), were isolated from the herb Huperzia serrata [2].
  • Huperzine A (HupA), extracted from a club moss (Huperzia serrata), is a sesquiterpene alkaloid and a powerful and reversible inhibitor of acetylcholinesterase (AChE) [3].


  1. The first complete chloroplast genome sequence of a lycophyte, Huperzia lucidula (Lycopodiaceae). Wolf, P.G., Karol, K.G., Mandoli, D.F., Kuehl, J., Arumuganathan, K., Ellis, M.W., Mishler, B.D., Kelch, D.G., Olmstead, R.G., Boore, J.L. Gene (2005) [Pubmed]
  2. New lycopodium alkaloids from Huperzia serrata. Tan, C.H., Wang, B.D., Jiang, S.H., Zhu, D.Y. Planta Med. (2002) [Pubmed]
  3. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Zangara, A. Pharmacol. Biochem. Behav. (2003) [Pubmed]
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