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Chemical Compound Review

DPOFA     2-[[(8aR)-3,4-dichloro-6-oxo- 8a-propyl-8,9...

Synonyms: AC1MHYLM, SureCN1888816, B-3(+), L-644,711, L 644711, ...
 
 
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Disease relevance of B-3(+)

  • However, chemokines and their receptors are also important in dendritic cell maturation (2), B (3), and T (4) cell development, Th1 and Th2 responses, infections, angiogenesis, and tumor growth as well as metastasis (5) [1].
  • Two points were arbitrarily selected on the steepest rising segment of the continuous wave mitral regurgitation velocity curve (point A, 1 m/sec, point B, 3 m/sec), and the time interval (t) between them was measured [2].
  • Teleocidin, isolated from mycelia of Streptomyces mediocidicus is a mixture of two teleocidin A isomers with molecular weights of 437 (A-1 and A-2) and four teleocidin B isomers with molecular weights of 451 (B-1, B-2, B-3, and B-4) [3].
  • Serum hepatitis B virus (HBV) DNA from 4 infants with fulminant hepatitis B, 3 infants with acute self-limited hepatitis B, and 15 infants with chronic HBV infection were amplified by polymerase chain reaction followed by direct sequencing of the region of HBV genome encoding the major antigenic epitopes of hepatitis B surface antigen (HBsAg) [4].
  • Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms [5].
 

High impact information on B-3(+)

  • Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3' hypervariable region [6].
  • Nucleotide sequence analysis of the apolipoprotein B 3' VNTR [7].
  • The B-3(+) at 50 microM alone had no effect on the thermosensitivity of cells, but it increased the thermosensitizing effect of HMA in acidic medium [8].
  • In the present study, we expressed wild type or R116C alphaA-crystallin in the human lens epithelial cell line HLE B-3 [9].
  • The introduction of alphaA-crystallin in the transformed human lens epithelial (HLE) B-3 lens epithelial cell line (which expresses low endogenous levels of alphaB-crystallin) led to a nearly complete protection of cell death induced by staurosporine, Fas monoclonal antibody, or the cytokine tumor necrosis factor alpha [10].
 

Chemical compound and disease context of B-3(+)

 

Biological context of B-3(+)

  • The present study demonstrates that CR-1 indirectly induces tyrosine phosphorylation of erb B-4 but not of the epidermal growth factor-related receptors erb B-2 and erb B-3 in different mouse and human mammary epithelial cell lines [16].
  • Lack of correlation between neutralizing antibody production and suppression of coxsackievirus B-3 replication in target organs: evidence for involvement of mononuclear inflammatory cells in host defense [17].
  • The second locus (B-2) contains the plasmid plus origin of replication and the third region (locus B-3) was located in the vicinity of a putative antisense RNA (RNAI) of unknown function [18].
  • Phylogenetic analysis of 24 putative proteins and polypeptides showed that the 22 CoV HKU1 strains fell into three clusters (genotype A, 13 strains; genotype B, 3 strains and genotype C, 6 strains) [19].
  • In Study B, both C + H groups (B-1, B-2) had a significantly greater (p less than 0.01) blood pressure reduction than that seen with C alone (B-3) [20].
 

Anatomical context of B-3(+)

  • Lysis of infected myofibers by coxsackievirus B-3-immune T lymphocytes [21].
  • Neither CTL population adsorbed to monolayers of HeLa, L929, or umbilical cord endothelial cells, or to myocytes infected with a related but nonmyocarditic Coxsackievirus B-3 variant ( CVB3o ) [22].
  • Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. III. Role of sex [23].
  • This report describes studies characterizing the virus-specific cytotoxic effector cells which are present in the spleens of mice 7 days after infection with Coxsackievirus B-3 [24].
  • The production of cytotoxic cells in the spleen of adult male BALB/c mice infected with Coxsackievirus B-3 has been examined.An in vitro 51Cr release assay was used to measure cytotoxic activity against virus-infected and uninfected neonatal sygeneic fibroblasts [25].
 

Associations of B-3(+) with other chemical compounds

  • Conversely, CR-1 was found not to directly bind to or to activate the tyrosine kinases associated with the EGFR, erb B-2, erb B-3, or erb B-4 either alone or in various pairwise combinations which have been ectopically expressed in Ba/F3 mouse pro-B lymphocyte cells [26].
  • HLE B-3 and alphaTN4 cells were transfected with pGRE.Luc and cotreated with dexamethasone, with and without the competitive inhibitor RU-486 [27].
  • METHODS: Total GSTs were purified from HLE B-3 cells by glutathione (GSH)-affinity chromatography and characterized by Western blot analysis, isoelectric focusing, and kinetic studies [28].
  • Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2 [28].
  • [structure: see text] Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii [29].
 

Gene context of B-3(+)

  • HLE B-3 cell membranes were prepared, peroxidized, and used to examine whether hGSTA1-1 and hGSTA2-2 catalyzes the reduction of membrane PL-OOH in situ using the microiodometric and spectrophotometric assays [28].
  • RESULTS: Dex treatment of B-3 and primary cultures demonstrated specific GR, but not mineralocorticoid receptor (MR), activation and phosphorylation [30].
  • METHODS: HLE B-3 cells and human lens epithelium explants from 17- to 20-week fetal lenses were cultured and treated with TGF-beta(2) (1 or 10 ng/mL), FGF-2 (20 or 50 ng/mL), HGF (10 ng/mL) and 5 or 10 muM MG132 [31].
  • However, H2O2 treatment lowered the levels of p27Kip1, cdc2, and PCNA in the rat lens culture, unlike in the HLE B-3 cells [32].
  • There are four putative NF-kappa B binding sites (kappa B-1, kappa B-2, kappa B-3, kappa B-4) in human TNF-alpha promoter [33].
 

Analytical, diagnostic and therapeutic context of B-3(+)

References

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  2. A new method for estimating left ventricular dP/dt by continuous wave Doppler-echocardiography. Validation studies at cardiac catheterization. Bargiggia, G.S., Bertucci, C., Recusani, F., Raisaro, A., de Servi, S., Valdes-Cruz, L.M., Sahn, D.J., Tronconi, L. Circulation (1989) [Pubmed]
  3. Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice. Fujiki, H., Suganuma, M., Ninomiya, M., Yoshizawa, S., Yamashita, K., Takayama, S., Hitotsuyanagi, Y., Sakai, S., Shudo, K., Sugimura, T. Cancer Res. (1988) [Pubmed]
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  5. Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms. Lodge, P.A., Herzum, M., Olszewski, J., Huber, S.A. Am. J. Pathol. (1987) [Pubmed]
  6. Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3' hypervariable region. Boerwinkle, E., Xiong, W.J., Fourest, E., Chan, L. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Nucleotide sequence analysis of the apolipoprotein B 3' VNTR. Ellsworth, D.L., Shriver, M.D., Boerwinkle, E. Hum. Mol. Genet. (1995) [Pubmed]
  8. Increase in thermosensitivity of tumor cells by lowering intracellular pH. Song, C.W., Lyons, J.C., Griffin, R.J., Makepeace, C.M., Cragoe, E.J. Cancer Res. (1993) [Pubmed]
  9. The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis. Andley, U.P., Patel, H.C., Xi, J.H. J. Biol. Chem. (2002) [Pubmed]
  10. Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells. Andley, U.P., Song, Z., Wawrousek, E.F., Fleming, T.P., Bassnett, S. J. Biol. Chem. (2000) [Pubmed]
  11. Coxsackievirus B-3-induced myocarditis. Virus and actinomycin D treatment of myocytes induces novel antigens recognized by cytolytic T lymphocytes. Huber, S.A., Heintz, N., Tracy, R. J. Immunol. (1988) [Pubmed]
  12. Coxsackievirus B-3 myocarditis. T-cell autoimmunity to heart antigens is resistant to cyclosporin-A treatment. Estrin, M., Smith, C., Huber, S. Am. J. Pathol. (1986) [Pubmed]
  13. In vitro evidence supporting two mechanisms of action for the anion transport inhibitor L-644,711 in cerebral ischaemia. Bednar, M.M., Kohut, J.J., Kimelberg, H.K., Gross, J.J., Gross, C.E. Neurol. Res. (1992) [Pubmed]
  14. Brevibacterium casei bacteremia and line sepsis in a patient with AIDS. Janda, W.M., Tipirneni, P., Novak, R.M. J. Infect. (2003) [Pubmed]
  15. Treatment of tyramine-induced brain edema with anion transport inhibitor L-644,711. Faraj, B.A., Cragoe, E.J., Sarper, R., Camp, M., Malveaux, E. Life Sci. (1988) [Pubmed]
  16. Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor. Bianco, C., Kannan, S., De Santis, M., Seno, M., Tang, C.K., Martinez-Lacaci, I., Kim, N., Wallace-Jones, B., Lippman, M.E., Ebert, A.D., Wechselberger, C., Salomon, D.S. J. Biol. Chem. (1999) [Pubmed]
  17. Lack of correlation between neutralizing antibody production and suppression of coxsackievirus B-3 replication in target organs: evidence for involvement of mononuclear inflammatory cells in host defense. Woodruff, J.F. J. Immunol. (1979) [Pubmed]
  18. Three regions in the DNA of plasmid pLS1 show sequence-directed static bending. Pérez-Martín, J., del Solar, G.H., de la Campa, A.G., Espinosa, M. Nucleic Acids Res. (1988) [Pubmed]
  19. Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. Woo, P.C., Lau, S.K., Yip, C.C., Huang, Y., Tsoi, H.W., Chan, K.H., Yuen, K.Y. J. Virol. (2006) [Pubmed]
  20. Influence of an angiotensin converting-enzyme inhibitor on diuretic-induced metabolic effects in hypertension. Weinberger, M.H. Hypertension (1983) [Pubmed]
  21. Lysis of infected myofibers by coxsackievirus B-3-immune T lymphocytes. Huber, S.A., Job, L.P., Woodruff, J.F. Am. J. Pathol. (1980) [Pubmed]
  22. Coxsackievirus B-3 myocarditis in Balb/c mice. Evidence for autoimmunity to myocyte antigens. Huber, S.A., Lodge, P.A. Am. J. Pathol. (1984) [Pubmed]
  23. Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. III. Role of sex. Wong, C.Y., Woodruff, J.J., Woodruff, J.F. J. Immunol. (1977) [Pubmed]
  24. Generation of cytotoxic T lymphocytes during coxsackievirus tb-3 infection. II. Characterization of effector cells and demonstration cytotoxicity against viral-infected myofibers1. Wong, C.Y., Woodruff, J.J., Woodruff, J.F. J. Immunol. (1977) [Pubmed]
  25. Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. I. Model and viral specificity1. Wong, C.Y., Woodruff, J.J., Woodruff, J.F. J. Immunol. (1977) [Pubmed]
  26. Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. Kannan, S., De Santis, M., Lohmeyer, M., Riese, D.J., Smith, G.H., Hynes, N., Seno, M., Brandt, R., Bianco, C., Persico, G., Kenney, N., Normanno, N., Martinez-Lacaci, I., Ciardiello, F., Stern, D.F., Gullick, W.J., Salomon, D.S. J. Biol. Chem. (1997) [Pubmed]
  27. Expression of the functional glucocorticoid receptor in mouse and human lens epithelial cells. Gupta, V., Wagner, B.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  28. Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Yang, Y., Sharma, R., Cheng, J.Z., Saini, M.K., Ansari, N.H., Andley, U.P., Awasthi, S., Awasthi, Y.C. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  29. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii. Pan, L., Zhou, P., Zhang, X., Peng, S., Ding, L., Qiu, S.X. Org. Lett. (2006) [Pubmed]
  30. Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells. Gupta, V., Awasthi, N., Wagner, B.J. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  31. Suppression of Human Lens Epithelial Cell Proliferation by Proteasome Inhibition, a Potential Defense against Posterior Capsular Opacification. Awasthi, N., Wagner, B.J. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  32. Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells. Seomun, Y., Kim, J.T., Kim, H.S., Park, J.Y., Joo, C.K. Mol. Vis. (2005) [Pubmed]
  33. Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B. Goto, M., Yamada, K., Katayama, K., Tanaka, I. Mol. Pharmacol. (1996) [Pubmed]
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