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MeSH Review:

Ankle Injuries

Petrella, R. et al., Sinha, A. et al., Ekman, E.F. et al., Sloan, J.P. et al., Agel, J. et al.

Agel, Bershadsky, Arendt, Petrella, Ekman, Schuller, Fort,

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High impact information on Ankle Injuries

Hormonal therapy: ACL and ankle injury [1].
METHOD: A study was carried out to document the nature of aeroball related incidents, between 1991 and 1995, at Lancaster University Sports Centre. Lace-up ankle supports were introduced in April 1992, and their effect on the incidence of ankle injury was recorded [2].
RESULTS: For the primary endpoints at day 4, the mean pain VAS scores were 31.9 mm +/- 1.96 for celecoxib and 29.0 mm +/- 1.91 for naproxen, and the responder rate for Patient's Global Assessment of Ankle Injury was 71% in the celecoxib group and 72% in the naproxen group, differences that were not statistically significant [3].
Immediate high-dose ibuprofen is therefore recommended as treatment for moderate to severe acute ankle injuries [4].

Chemical compound and disease context of Ankle Injuries

Patient's Global Assessment of Ankle Injury responses, given on days 4 and 8, showed that the celecoxib group improved significantly more than the placebo group did, with 67% of the celecoxib group versus 55% of the placebo group improving at day 4 (P < .05) [5].

References

Hormonal therapy: ACL and ankle injury. Agel, J., Bershadsky, B., Arendt, E.A. Medicine and science in sports and exercise. (2006) [Pubmed]
Study of aeroball injuries. Sinha, A., McGlone, R.G., Montgomery, K. British journal of sports medicine. (1997) [Pubmed]
Efficacy of celecoxib, a COX-2-specific inhibitor, and naproxen in the management of acute ankle sprain: results of a double-blind, randomized controlled trial. Petrella, R., Ekman, E.F., Schuller, R., Fort, J.G. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine. (2004) [Pubmed]
Benefits of early anti-inflammatory medication following acute ankle injury. Sloan, J.P., Hain, R., Pownall, R. Injury. (1989) [Pubmed]
Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. Ekman, E.F., Fiechtner, J.J., Levy, S., Fort, J.G. Am J. Orthop. (2002) [Pubmed]

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