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Chemical Compound Review

Ibumetin     2-[4-(2- methylpropyl)phenyl]propanoic acid

Synonyms: Salprofen, ibuprofen, Brufen, Motrin, Nuprin, ...
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Disease relevance of ibuprofen


Psychiatry related information on ibuprofen


High impact information on ibuprofen


Chemical compound and disease context of ibuprofen


Biological context of ibuprofen

  • In a double-blind trial, 85 patients, 5 to 39 years of age, with mild lung disease (forced expiratory volume in one second [FEV1], > or = 60 percent of the predicted value) were randomly assigned to receive ibuprofen or placebo orally twice daily for four years [4].
  • In animals given endotoxin followed by ibuprofen, a similar initial drop of systemic blood pressure was seen, but it subsequently recovered to 150.2 +/- 4.1 mm Hg by 120 min (P less than 0.001) [18].
  • Thus, ibuprofen may prevent iron-mediated generation of oxidants or iron-mediated lipid peroxidation after phosgene exposure [19].
  • We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation [20].
  • We have recently defined a region of the E-selectin lectin domain that appears to be directly involved with carbohydrate recognition and cell adhesion (Erbe, D. V., B. A. Wolitzky, L. G. Presta, C. R. Norton, R. J. Ramos, D. K. Burns, R. M. Rumberger, B. N. N. Rao, C. Foxall, B. K. Brandley, and L. A. Lasky. 1992. J. Cell Biol. 119:215-227) [21].

Anatomical context of ibuprofen

  • Among a number of other possibly serious adverse drug events, low white blood cell count was marginally associated with ibuprofen treatment [22].
  • We determined whether ibuprofen would also inhibit the forskolin-stimulated Isc in primary cultures of mouse trachea epithelia (MTE) and human bronchial epithelia (HBE) [23].
  • A previously healthy child who developed acute, severe, rapidly progressive vanishing bile duct syndrome shortly after Stevens-Johnson syndrome is described; this was temporally associated with ibuprofen use [24].
  • The animals were randomized into three treatment groups (n = 6): either CVF (125 units/kg) or saline was given 30 minutes after coronary artery ligation, and ibuprofen (12.5 mg/kg) was administered 30 minutes and 4 hours after ligation [25].
  • Additional experiments were carried out in rabbit aortas to determine the roles of the endothelium, extracellular calcium, indomethacin, ibuprofen, and calcium-channel blockade in modulating angioplasty-induced vasoconstriction [26].

Associations of ibuprofen with other chemical compounds

  • The mean improvement (change) in the scores on the pain scale of the Health Assessment Questionnaire was 0.33 with acetaminophen (95 percent confidence interval, 0.14 to 0.52), 0.30 with the low dose of ibuprofen (95 percent confidence interval, 0.09 to 0.51), and 0.35 with the high dose of ibuprofen (95 percent confidence interval, 0.13 to 0.57) [1].
  • INTERVENTIONS: Patients were randomly assigned to receive celecoxib, 400 mg twice per day (2 and 4 times the maximum RA and OA dosages, respectively; n = 3987); ibuprofen, 800 mg 3 times per day (n = 1985); or diclofenac, 75 mg twice per day (n = 1996) [27].
  • Because of these apparent side effects, we stress caution in the use of ibuprofen in systemic lupus erythematosus, particularly if there is any history of salicylate intolerance [28].
  • This trend reflected the increased release of IL-8 by the subjects receiving ibuprofen compared to pentoxifylline (1.9-fold higher; p = 0.024) [29].
  • Nystatin was employed to selectively permeabilize the basolateral or apical membrane to determine the effect of ibuprofen on apical Cl- (ICl) and basolateral K+ (IK) currents after stimulation by forskolin [23].

Gene context of ibuprofen

  • The cyclooxygenase inhibitor ibuprofen and the adenylyl cyclase inhibitor SQ22536 both blunted the growth inhibitory effect of ET-1 [30].
  • Studies with PHO1 promoter-beta-glucuronidase constructs reveal predominant expression of the PHO1 promoter in the stelar cells of the root and the lower part of the hypocotyl [31].
  • Ibuprofen was more potent as an inhibitor of COX-2 in intact cells than in either broken cells or purified enzymes [32].
  • Thus, ibuprofen blunts growth factor-induced increase in ETB receptors [33].
  • Nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and diclofenac inhibit both COX-1 and COX-2 [34].

Analytical, diagnostic and therapeutic context of ibuprofen


  1. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. Bradley, J.D., Brandt, K.D., Katz, B.P., Kalasinski, L.A., Ryan, S.I. N. Engl. J. Med. (1991) [Pubmed]
  2. Ibuprofen and patent ductus arteriosus. Clyman, R.I. N. Engl. J. Med. (2000) [Pubmed]
  3. Ibuprofen in patients with cystic fibrosis. Carter, E.R., Moffitt, D.R. N. Engl. J. Med. (1995) [Pubmed]
  4. Effect of high-dose ibuprofen in patients with cystic fibrosis. Konstan, M.W., Byard, P.J., Hoppel, C.L., Davis, P.B. N. Engl. J. Med. (1995) [Pubmed]
  5. Ibuprofen in patients with sepsis. Zimmerli, W., Widmer, A.F. N. Engl. J. Med. (1997) [Pubmed]
  6. Ibuprofen, inflammation and Alzheimer disease. Wyss-Coray, T., Mucke, L. Nat. Med. (2000) [Pubmed]
  7. Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Harris, R.E., Chlebowski, R.T., Jackson, R.D., Frid, D.J., Ascenseo, J.L., Anderson, G., Loar, A., Rodabough, R.J., White, E., McTiernan, A. Cancer Res. (2003) [Pubmed]
  8. Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Bickel, A., Dorfs, S., Schmelz, M., Forster, C., Uhl, W., Handwerker, H.O. Pain (1998) [Pubmed]
  9. Possible effects of ibuprofen pretreatment on seizure duration during electroconvulsive therapy. Kessler, M.N. The Journal of clinical psychiatry. (2004) [Pubmed]
  10. Some biochemical correlates of panic attacks with agoraphobia and their response to a new treatment. Sheehan, D.V., Coleman, J.H., Greenblatt, D.J., Jones, K.J., Levine, P.H., Orsulak, P.J., Peterson, M., Schildkraut, J.J., Uzogara, E., Watkins, D. Journal of clinical psychopharmacology. (1984) [Pubmed]
  11. Cyclooxygenases: structural, cellular, and molecular biology. Smith, W.L., DeWitt, D.L., Garavito, R.M. Annu. Rev. Biochem. (2000) [Pubmed]
  12. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. Catella-Lawson, F., Reilly, M.P., Kapoor, S.C., Cucchiara, A.J., DeMarco, S., Tournier, B., Vyas, S.N., FitzGerald, G.A. N. Engl. J. Med. (2001) [Pubmed]
  13. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. Van Overmeire, B., Smets, K., Lecoutere, D., Van de Broek, H., Weyler, J., Degroote, K., Langhendries, J.P. N. Engl. J. Med. (2000) [Pubmed]
  14. Identification and disruption of a plant shaker-like outward channel involved in K+ release into the xylem sap. Gaymard, F., Pilot, G., Lacombe, B., Bouchez, D., Bruneau, D., Boucherez, J., Michaux-Ferrière, N., Thibaud, J.B., Sentenac, H. Cell (1998) [Pubmed]
  15. Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis. Kovesi, T.A., Swartz, R., MacDonald, N. N. Engl. J. Med. (1998) [Pubmed]
  16. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. Bernard, G.R., Wheeler, A.P., Russell, J.A., Schein, R., Summer, W.R., Steinberg, K.P., Fulkerson, W.J., Wright, P.E., Christman, B.W., Dupont, W.D., Higgins, S.B., Swindell, B.B. N. Engl. J. Med. (1997) [Pubmed]
  17. Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. Snapper, J.R., Hutchison, A.A., Ogletree, M.L., Brigham, K.L. J. Clin. Invest. (1983) [Pubmed]
  18. Ibuprofen in canine endotoxin shock. Jacobs, E.R., Soulsby, M.E., Bone, R.C., Wilson, F.J., Hiller, F.C. J. Clin. Invest. (1982) [Pubmed]
  19. Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. Kennedy, T.P., Rao, N.V., Noah, W., Michael, J.R., Jafri, M.H., Gurtner, G.H., Hoidal, J.R. J. Clin. Invest. (1990) [Pubmed]
  20. Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants. Gournay, V., Savagner, C., Thiriez, G., Kuster, A., Rozé, J.C. Lancet (2002) [Pubmed]
  21. P- and E-selectin use common sites for carbohydrate ligand recognition and cell adhesion. Erbe, D.V., Watson, S.R., Presta, L.G., Wolitzky, B.A., Foxall, C., Brandley, B.K., Lasky, L.A. J. Cell Biol. (1993) [Pubmed]
  22. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial. Lesko, S.M., Mitchell, A.A. JAMA (1995) [Pubmed]
  23. Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator-mediated Cl- secretion. Devor, D.C., Schultz, B.D. J. Clin. Invest. (1998) [Pubmed]
  24. Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child. Srivastava, M., Perez-Atayde, A., Jonas, M.M. Gastroenterology (1998) [Pubmed]
  25. Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury. Crawford, M.H., Grover, F.L., Kolb, W.P., McMahan, C.A., O'Rourke, R.A., McManus, L.M., Pinckard, R.N. Circulation (1988) [Pubmed]
  26. Endothelium-dependent arterial vasoconstriction after balloon angioplasty. Fischell, T.A., Nellessen, U., Johnson, D.E., Ginsburg, R. Circulation (1989) [Pubmed]
  27. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. Silverstein, F.E., Faich, G., Goldstein, J.L., Simon, L.S., Pincus, T., Whelton, A., Makuch, R., Eisen, G., Agrawal, N.M., Stenson, W.F., Burr, A.M., Zhao, W.W., Kent, J.D., Lefkowith, J.B., Verburg, K.M., Geis, G.S. JAMA (2000) [Pubmed]
  28. Acute adverse reactions to ibuprofen in systemic lupus erythematosus. Finch, W.R., Strottman, M.P. JAMA (1979) [Pubmed]
  29. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. Martich, G.D., Danner, R.L., Ceska, M., Suffredini, A.F. J. Exp. Med. (1991) [Pubmed]
  30. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Mallat, A., Préaux, A.M., Serradeil-Le Gal, C., Raufaste, D., Gallois, C., Brenner, D.A., Bradham, C., Maclouf, J., Iourgenko, V., Fouassier, L., Dhumeaux, D., Mavier, P., Lotersztajn, S. J. Clin. Invest. (1996) [Pubmed]
  31. Identification and characterization of the Arabidopsis PHO1 gene involved in phosphate loading to the xylem. Hamburger, D., Rezzonico, E., MacDonald-Comber Petétot, J., Somerville, C., Poirier, Y. Plant Cell (2002) [Pubmed]
  32. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., Flower, R.J., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  33. Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/cyclic AMP pathway and cross-talk with endothelin receptors. Mallat, A., Gallois, C., Tao, J., Habib, A., Maclouf, J., Mavier, P., Préaux, A.M., Lotersztajn, S. J. Biol. Chem. (1998) [Pubmed]
  34. Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans. Schwartz, J.I., Chan, C.C., Mukhopadhyay, S., McBride, K.J., Jones, T.M., Adcock, S., Moritz, C., Hedges, J., Grasing, K., Dobratz, D., Cohen, R.A., Davidson, M.H., Bachmann, K.A., Gertz, B.J. Clin. Pharmacol. Ther. (1999) [Pubmed]
  35. The bleeding time is longer than normal in hemophilia. Eyster, M.E., Gordon, R.A., Ballard, J.O. Blood (1981) [Pubmed]
  36. Altered coronary vascular responsiveness to leukotrienes in alloxan-diabetic rats. Roth, D.M., Reibel, D.K., Lefer, A.M. Circ. Res. (1984) [Pubmed]
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