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MeSH Review:

Uterine Diseases

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Disease relevance of Uterine Diseases

Detectable serum IL-6 levels were found in 9% of patients with benign uterine diseases, 11% of patients with CIN, 44% of patients with cervical cancer and 11% of patients with endometrial cancer [1].
Serum levels of CYFRA 21-1 (cut-off = 1.06 ng/mL) and SCC (cut-off = 2 ng/mL) were measured in blood samples collected before treatment from 15 patients with cervical intraepithelial neoplasia (CIN), 56 patients with cervical cancer, 48 patients with endometrial cancer, and 361 patients with benign uterine diseases [2].

High impact information on Uterine Diseases

Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment [3].
Normal tissue from patients with SCC showed significantly higher triglycerides than normal tissue from patients with benign uterine disease but significantly lower triglycerides than SCC tissue [4].
DESIGN AND PATIENTS: Thirty-seven fertile women undergoing surgery for benign uterine diseases were divided into 3 groups and monitored for 12 months: hysterectomized women (n = 9), ovariectomized untreated women (n = 12) and ovariectomized women starting treatment with transdermal estradiol (E2, 50 microg/d) 1 month after surgery (n = 16) [5].

Gene context of Uterine Diseases

Pretreatment serum levels of soluble interleukin-2 receptor (sIL-2R), CA 125, and SCC were measured in 183 patients with malignant or benign uterine diseases [6].

References

Serum interleukin-6 levels in uterine malignancies. Preliminary data. Ferdeghini, M., Gadducci, A., Prontera, C., Bonuccelli, A., Annicchiarico, C., Fanucchi, A., Facchini, V., Bianchi, R. Anticancer Res. (1994) [Pubmed]
Serum CYFRA 21-1 assay in squamous cell carcinoma of the cervix. Ferdeghini, M., Gadducci, A., Annicchiarico, C., Prontera, C., Malagnino, G., Castellani, C., Facchini, V., Bianchi, R. Anticancer Res. (1993) [Pubmed]
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Bulun, S.E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., Langoi, D., Deb, S. Pharmacol. Rev. (2005) [Pubmed]
Preinvasive and invasive cervical cancer: an ex vivo proton magic angle spinning magnetic resonance spectroscopy study. Mahon, M.M., deSouza, N.M., Dina, R., Soutter, W.P., McIndoe, G.A., Williams, A.D., Cox, I.J. NMR in biomedicine. (2004) [Pubmed]
Oestrogens prevent the increase of human serum soluble interleukin-6 receptor induced by ovariectomy in vivo and decrease its release in human osteoblastic cells in vitro. Girasole, G., Giuliani, N., Modena, A.B., Passeri, G., Pedrazzoni, M. Clin. Endocrinol. (Oxf) (1999) [Pubmed]
Serum soluble interleukin-2 receptor (sIL-2R) assay in cervical and endometrial cancer. Preliminary data. Ferdeghini, M., Gadducci, A., Prontera, C., Marrai, R., Malagnino, G., Annicchiarico, C., Fioretti, P., Bianchi, R. Anticancer Res. (1993) [Pubmed]

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