Gene Review:
IL2 - interleukin 2
Homo sapiens
Synonyms:
IL-2, Interleukin-2, T-cell growth factor, TCGF, lymphokine
Signore,
Innocenzi,
Bottoni,
Barone,
D'Alessandria,
Annovazzi,
Calvieri,
Mather,
Panetta,
Chianelli,
Bonanno,
Scopinaro,
Zhang,
Cao,
Wu,
Shen,
Zhang,
Zhou,
Isakov,
Altman,
Na Fang,
Feng-Tong Gao,
Peng Fu,
Yong Li,
Duo Ma,
Hui-Qi Gao,
Hai-Shan Yang,
Zhi-Jie Yang,
Yan-Song Xu,
Corcos,
Guilbaud,
Paterniti,
Moussa,
Chambry,
Jeammet,
Flament,
Speranza,
Chaouat,
Cayol,
Waldmann,
Ma,
Burkett,
Koka,
Lenardo,
Hornung,
Wang,
Siegel,
Chan,
Zheng,
McFarland,
De Paoli,
Crepaldi,
Tirelli,
Simonelli,
Comar,
Giacca,
D'Andrea,
Talamini,
Bortolin,
Zanussi,
- Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin. Gascon, P., Zoumbos, N.C., Scala, G., Djeu, J.Y., Moore, J.G., Young, N.S. Blood (1985)
- Costimulation of cutaneous T-cell lymphoma cells by interleukin-7 and interleukin-2: potential autocrine or paracrine effectors in the Sézary syndrome. Foss, F.M., Koc, Y., Stetler-Stevenson, M.A., Nguyen, D.T., O'Brien, M.C., Turner, R., Sausville, E.A. J. Clin. Oncol. (1994)
- Evidence for local and systemic activation of immune cells by peritumoral injections of interleukin 2 in patients with advanced squamous cell carcinoma of the head and neck. Whiteside, T.L., Letessier, E., Hirabayashi, H., Vitolo, D., Bryant, J., Barnes, L., Snyderman, C., Johnson, J.T., Myers, E., Herberman, R.B. Cancer Res. (1993)
- Interleukin 2 and interferon-gamma augment anticolon antibody dependent cellular cytotoxicity in ulcerative colitis. Hibi, T., Ohara, M., Watanabe, M., Kanai, T., Takaishi, H., Hayashi, A., Hosoda, Y., Ogata, H., Iwao, Y., Aiso, S. Gut (1993)
- 99mTc-interleukin-2 scintigraphy as a potential tool for evaluating tumor-infiltrating lymphocytes in melanoma lesions: a validation study. Signore, A., Annovazzi, A., Barone, R., Bonanno, E., D'Alessandria, C., Chianelli, M., Mather, S.J., Bottoni, U., Panetta, C., Innocenzi, D., Scopinaro, F., Calvieri, S. J. Nucl. Med. (2004)
- Serum concentrations of IL-2 and TNF-alpha in patients with painful bone metastases: correlation with responses to 89SrCl2 therapy. Fang, N., Li, Y., Xu, Y.S., Ma, D., Fu, P., Gao, H.Q., Gao, F.T., Yang, H.S., Yang, Z.J. J. Nucl. Med. (2006)
- Lowered serum dipeptidyl peptidase IV activity is associated with depressive symptoms and cytokine production in cancer patients receiving interleukin-2-based immunotherapy. Maes, M., Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Egyed, B., Dantzer, R., Neveu, P.J. Neuropsychopharmacology (2001)
- Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Zhang, X.Y., Zhou, D.F., Zhang, P.Y., Wu, G.Y., Cao, L.Y., Shen, Y.C. Schizophr. Res. (2002)
- Cytokines and anorexia nervosa. Corcos, M., Guilbaud, O., Chaouat, G., Cayol, V., Speranza, M., Chambry, J., Paterniti, S., Moussa, M., Flament, M., Jeammet, P. Psychosomatic medicine. (2001)
- Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men. Lange, T., Marshall, L., Späth-Schwalbe, E., Fehm, H.L., Born, J. Brain Behav. Immun. (2002)
- Interleukin-2-induced increase of a monoclonal B-cell lymphocytosis. A novel in vivo interleukin-2 effect? Tiberghien, P., Racadot, E., Deschaseaux, M.L., Delain, M., Voillat, L., Billot, M., Flesch, M., Rozenbaum, A., Brandely, M., Cahn, J.Y. Cancer (1992)
- Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Ma, A., Koka, R., Burkett, P. Annu. Rev. Immunol. (2006)
- The meandering 45-year odyssey of a clinical immunologist. Waldmann, T.A. Annu. Rev. Immunol. (2003)
- T cell anergy. Schwartz, R.H. Annu. Rev. Immunol. (2003)
- Protein kinase C(theta) in T cell activation. Isakov, N., Altman, A. Annu. Rev. Immunol. (2002)
- Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Lenardo, M., Chan, K.M., Hornung, F., McFarland, H., Siegel, R., Wang, J., Zheng, L. Annu. Rev. Immunol. (1999)
- Induction of MUC1-specific cellular immunity by a recombinant BCG expressing human MUC1 and secreting IL2. He, J., Shen, D., O'Donnell, M.A., Chang, H.R. Int. J. Oncol. (2002)
- Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures. Arzt, E., Stelzer, G., Renner, U., Lange, M., Müller, O.A., Stalla, G.K. J. Clin. Invest. (1992)
- Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects. De Paoli, P., Zanussi, S., Simonelli, C., Bortolin, M.T., D'Andrea, M., Crepaldi, C., Talamini, R., Comar, M., Giacca, M., Tirelli, U. J. Clin. Invest. (1997)
- Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro. Tsang, K.Y., Fudenberg, H.H., Galbraith, G.M., Donnelly, R.P., Bishop, L.R., Koopmann, W.R. J. Clin. Invest. (1985)
- Maturation of acute T-lymphoblastic leukemia cells after CD2 ligation and subsequent treatment with interleukin-2. Mentz, F., Ouaaz, F., Michel, A., Blanc, C., Hervé, P., Bismuth, G., Debré, P., Merle-Béral, H., Mossalayi, M.D. Blood (1994)
- Transduction of the IL2 gene into human acute leukemia cells: induction of tumor rejection without modifying cell proliferation and IL2 receptor expression. Cignetti, A., Guarini, A., Carbone, A., Forni, M., Cronin, K., Forni, G., Gansbacher, B., Foa, R. J. Natl. Cancer Inst. (1994)
- Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Schwarz, E.M., Salgame, P., Bloom, B.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Differential inhibition of interleukin 2- and interleukin 4-mediated human B cell proliferation by ionomycin: a possible regulatory role for apoptosis. Vazquez, A., Auffredou, M.T., Chaouchi, N., Taieb, J., Sharma, S., Galanaud, P., Leca, G. Eur. J. Immunol. (1991)
- Interferon-alpha can synergize with interleukin 2 for human in vitro antibody response. Delfraissy, J.F., Wallon, C., Galanaud, P. Eur. J. Immunol. (1988)
- Induction of lymphokine-activated killer activity by interleukin 4 in human lymphocytes preactivated by interleukin 2 in vivo or in vitro. Higuchi, C.M., Thompson, J.A., Lindgren, C.G., Gillis, S., Widmer, M.B., Kern, D.E., Fefer, A. Cancer Res. (1989)
- Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets. Casolaro, V., Georas, S.N., Song, Z., Zubkoff, I.D., Abdulkadir, S.A., Thanos, D., Ono, S.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated. Mills, G.B., May, C., McGill, M., Fung, M., Baker, M., Sutherland, R., Greene, W.C. J. Biol. Chem. (1990)
- Activation signals via CD2 molecule and interleukin 2 receptor act in synergy for helper function induction. Hu, J., Vaquero, C., Bismuth, G., Eljaafari, A., Bernard, A., Levy, J.P., Sterkers, G. Eur. J. Immunol. (1988)
- Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Wang, J., Barke, R.A., Roy, S. J. Biol. Chem. (2007)
- A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma. Eigentler, T.K., Weide, B., de Braud, F., Spitaleri, G., Romanini, A., Pflugfelder, A., González-Iglesias, R., Tasciotti, A., Giovannoni, L., Schwager, K., Lovato, V., Kaspar, M., Trachsel, E., Menssen, H.D., Neri, D., Garbe, C. Clin. Cancer Res. (2011)
- Differential effects of gangliosides on Ig production and proliferation by human B cells. Kimata, H., Yoshida, A. Blood (1994)
- Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding. Parra, E., Varga, M., Hedlund, G., Kalland, T., Dohlsten, M. Mol. Cell. Biol. (1997)
- T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis. Hombach, A., Sent, D., Schneider, C., Heuser, C., Koch, D., Pohl, C., Seliger, B., Abken, H. Cancer Res. (2001)
- Functional disparity of distinct CD28 response elements toward mitogenic responses. Civil, A., Rensink, I., Aarden, L.A., Verweij, C.L. J. Biol. Chem. (1999)
- Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene. Taylor, N., Uribe, L., Smith, S., Jahn, T., Kohn, D.B., Weinberg, K. Blood (1996)
- SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Cohney, S.J., Sanden, D., Cacalano, N.A., Yoshimura, A., Mui, A., Migone, T.S., Johnston, J.A. Mol. Cell. Biol. (1999)
- CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Ahmed-Choudhury, J., Williams, K.T., Young, L.S., Adams, D.H., Afford, S.C. Cell. Signal. (2006)
- Legionella pneumophila protease inactivates interleukin-2 and cleaves CD4 on human T cells. Mintz, C.S., Miller, R.D., Gutgsell, N.S., Malek, T. Infect. Immun. (1993)
- CD45 ligation in T cells regulates signal transduction through both the interleukin-2 receptor and the CD3/Ti T-cell receptor complex. Gilliland, L.K., Schieven, G.L., Grosmaire, L.S., Damle, N.K., Ledbetter, J.A. Tissue Antigens (1990)
- E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. Rilo, H.L., Carroll, P.B., Subbotin, V., Johnson, N., Van Thiel, D.H., Thomson, A.W. Acta Derm. Venereol. (1994)
- Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Miyazaki, T., Kawahara, A., Fujii, H., Nakagawa, Y., Minami, Y., Liu, Z.J., Oishi, I., Silvennoinen, O., Witthuhn, B.A., Ihle, J.N. Science (1994)
- Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4). Widmer, M.B., Acres, R.B., Sassenfeld, H.M., Grabstein, K.H. J. Exp. Med. (1987)
- Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. Armant, M., Ishihara, H., Rubio, M., Delespesse, G., Sarfati, M. J. Exp. Med. (1994)
- Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood. Alderson, M.R., Sassenfeld, H.M., Widmer, M.B. J. Exp. Med. (1990)
- The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. McInnes, I.B., al-Mughales, J., Field, M., Leung, B.P., Huang, F.P., Dixon, R., Sturrock, R.D., Wilkinson, P.C., Liew, F.Y. Nat. Med. (1996)
- The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Selvaraj, P., Plunkett, M.L., Dustin, M., Sanders, M.E., Shaw, S., Springer, T.A. Nature (1987)
- Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Freeman, G.J., Gribben, J.G., Boussiotis, V.A., Ng, J.W., Restivo, V.A., Lombard, L.A., Gray, G.S., Nadler, L.M. Science (1993)
- Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Cai, Y.C., Cefai, D., Schneider, H., Raab, M., Nabavi, N., Rudd, C.E. Immunity (1995)
- Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. Penix, L., Weaver, W.M., Pang, Y., Young, H.A., Wilson, C.B. J. Exp. Med. (1993)
- Differentiation factors for human specific B cell response. Vazquez, A., Gerard, J.P., Delfraissy, J.F., Dugas, B., Auffredou, M.T., Crevon, M.C., Fradelizi, D., Galanaud, P. Eur. J. Immunol. (1986)