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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CLIP-170 highlights growing microtubule ends in vivo.

A chimera with the green fluorescent protein (GFP) has been constructed to visualize the dynamic properties of the endosome-microtubule linker protein CLIP170 (GFP-CLIP170). GFP-CLIP170 binds in stretches along a subset of microtubule ends. These fluorescent stretches appear to move with the growing tips of microtubules at 0.15-0.4 microm/s, comparable to microtubule elongation in vivo. Analysis of speckles along dynamic GFP-CLIP170 stretches suggests that CLIP170 treadmills on growing microtubule ends, rather than being continuously transported toward these ends. Drugs affecting microtubule dynamics rapidly inhibit movement of GFP-CLIP170 dashes. We propose that GFP-CLIP170 highlights growing microtubule ends by specifically recognizing the structure of a segment of newly polymerized tubulin.[1]

References

  1. CLIP-170 highlights growing microtubule ends in vivo. Perez, F., Diamantopoulos, G.S., Stalder, R., Kreis, T.E. Cell (1999) [Pubmed]
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