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Gene Review

CLIP1  -  CAP-GLY domain containing linker protein 1

Homo sapiens

Synonyms: CAP-Gly domain-containing linker protein 1, CLIP, CLIP-170, CLIP170, CYLN1, ...
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Disease relevance of CLIP1


High impact information on CLIP1


Biological context of CLIP1


Anatomical context of CLIP1


Associations of CLIP1 with chemical compounds

  • In vivo, CLIP-170 colocalizes with a subset of transferrin receptor-positive endocytic structures and, more extensively, with endosomal tubules induced by brefeldin A [5].
  • The NH2-terminal self-association domain of LIS1 displaces endogenous LIS1 from the kinetochore, with no effect on CLIP-170, dynein, and dynactin [11].
  • Cells that drive muscle vasoconstrictor (MVC), cutaneous vasoconstrictor (CVC), visceral vasoconstrictor (VVC) and renal sympathetic (RSN) outflows have been identified among the premotor neurons of the rostral ventrolateral medulla (RVLM) [12].
  • In Study 1, four groups (N = 36) of restorative materials; (1) resin composite (RSN), (2) resin-modified glass ionomer (RMGI), (3) conventional glass ionomer (CGI), and (4) porcelain (PCN), were subjected to a rinse in either tap water (control) or Pyrromethene 556 dye at a concentration of 0.01M for 30 seconds or 0.0015 M for 60 seconds [13].
  • We show that photolabeling of the COOH-proximal site by LY475776 and the labeling of both NH(2)- and COOH- proximal sites by azidophenacyl-GSH requires the cytoplasmic linker (CL3) region connecting the first and second MSDs of the protein, but not the first MSD itself [14].

Physical interactions of CLIP1

  • CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms [15].
  • In this study, we also mapped the minimum binding domains (mBDPs) of PS1 and CLIP-70 to regions corresponding to the N-terminal end of the large cytoplasmic loop of PS1 and the metal binding motif-containing C-terminal end of CLIP-170 [16].
  • These results document that CLIP-170 is a highly elongated polar molecule with the microtubule-binding domain and the organelle-interacting domains at opposite ends of the homodimer, thus providing a structural basis for the function of CLIP-170 as a microtubule-organelle linker protein [17].

Other interactions of CLIP1


Analytical, diagnostic and therapeutic context of CLIP1


  1. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. Hilliker, C., Delabie, J., Speleman, F., Bilbe, G., Bruggen, J., Van Leuven, F., Van den Berghe, H. Cytogenet. Cell Genet. (1994) [Pubmed]
  2. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Delabie, J., Shipman, R., Brüggen, J., De Strooper, B., van Leuven, F., Tarcsay, L., Cerletti, N., Odink, K., Diehl, V., Bilbe, G. Blood (1992) [Pubmed]
  3. Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation. Wan, X., Chen, S., Sadeghpour, A., Wang, Q., Kirsch, G.E. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  4. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F., Kaibuchi, K. Cell (2002) [Pubmed]
  5. CLIP-170 links endocytic vesicles to microtubules. Pierre, P., Scheel, J., Rickard, J.E., Kreis, T.E. Cell (1992) [Pubmed]
  6. CLIP-170 facilitates the formation of kinetochore-microtubule attachments. Tanenbaum, M.E., Galjart, N., van Vugt, M.A., Medema, R.H. EMBO J. (2006) [Pubmed]
  7. CLIP-170 highlights growing microtubule ends in vivo. Perez, F., Diamantopoulos, G.S., Stalder, R., Kreis, T.E. Cell (1999) [Pubmed]
  8. A dynein loading zone for retrograde endosome motility at microtubule plus-ends. Lenz, J.H., Schuchardt, I., Straube, A., Steinberg, G. EMBO J. (2006) [Pubmed]
  9. Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. Sahin, U., Neumann, F., Tureci, O., Schmits, R., Perez, F., Pfreundschuh, M. Blood (2002) [Pubmed]
  10. Molecular characterization of two functional domains of CLIP-170 in vivo. Pierre, P., Pepperkok, R., Kreis, T.E. J. Cell. Sci. (1994) [Pubmed]
  11. Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function. Tai, C.Y., Dujardin, D.L., Faulkner, N.E., Vallee, R.B. J. Cell Biol. (2002) [Pubmed]
  12. Functional anatomy of sympathetic premotor cell groups in the medulla. McAllen, R.M., May, C.N., Shafton, A.D. Clin. Exp. Hypertens. (1995) [Pubmed]
  13. Effect of two fluorescent dyes on color of restorative materials. Ferreira Zandoná, A.G., Kleinrichert, T., Analoui, M., Schemehorn, B.R., Eckert, G.J., Stookey, G.K. American journal of dentistry. (1997) [Pubmed]
  14. Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione. Qian, Y.M., Grant, C.E., Westlake, C.J., Zhang, D.W., Lander, P.A., Shepard, R.L., Dantzig, A.H., Cole, S.P., Deeley, R.G. J. Biol. Chem. (2002) [Pubmed]
  15. CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms. Goodson, H.V., Skube, S.B., Stalder, R., Valetti, C., Kreis, T.E., Morrison, E.E., Schroer, T.A. Cell Motil. Cytoskeleton (2003) [Pubmed]
  16. Microtubular interactions of presenilin direct kinesis of Abeta peptide and its precursors. Tezapsidis, N., Merz, P.A., Merz, G., Hong, H. FASEB J. (2003) [Pubmed]
  17. Purification and analysis of authentic CLIP-170 and recombinant fragments. Scheel, J., Pierre, P., Rickard, J.E., Diamantopoulos, G.S., Valetti, C., van der Goot, F.G., Häner, M., Aebi, U., Kreis, T.E. J. Biol. Chem. (1999) [Pubmed]
  18. Proposal of a modified Cancer of the Liver Italian Program staging system based on the model for end-stage liver disease for patients with hepatocellular carcinoma undergoing loco-regional therapy. Huo, T.I., Huang, Y.H., Lin, H.C., Wu, J.C., Chiang, J.H., Lee, P.C., Chang, F.Y., Lee, S.D. Am. J. Gastroenterol. (2006) [Pubmed]
  19. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Mimori-Kiyosue, Y., Grigoriev, I., Sasaki, H., Matsui, C., Akhmanova, A., Tsukita, S., Vorobjev, I. Genes Cells (2006) [Pubmed]
  20. Roles of IQGAP1 in cell polarization and migration. Watanabe, T., Noritake, J., Kaibuchi, K. Novartis Found. Symp. (2005) [Pubmed]
  21. Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. Ho, S.M., Lau, K.M., Mok, S.C., Syed, V. Oncogene (2003) [Pubmed]
  22. fMRI resting state networks define distinct modes of long-distance interactions in the human brain. De Luca, M., Beckmann, C.F., De Stefano, N., Matthews, P.M., Smith, S.M. Neuroimage (2006) [Pubmed]
  23. Comparison of the accuracy of two tests with a confirmatory procedure limited to positive results. Cheng, H., Macaluso, M. Epidemiology (Cambridge, Mass.) (1997) [Pubmed]
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