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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Aspects of melatonin manufacturing and requirements for a reliable active component.

Commercially available melatonin was found to contain impurities associated with eosinophilia-myalgia syndrome (EMS). From sample analysis, remarkable differences in impurity profiles between the active ingredient from various suppliers could be found. An industrial process was developed which guarantees a high purity melatonin active ingredient. All potential impurities have been characterized and synthetized for analytical conformity with pharmaceutical regulations. To avoid any side effects from impurities, only high-purity melatonin should be utilized from the laboratory through to commercialization.[1]

References

  1. Aspects of melatonin manufacturing and requirements for a reliable active component. Laforce, R., Rigozzi, K., Paganetti, M., Mossi, W., Guainazzi, P., Calderari, G. Biological signals and receptors. (1999) [Pubmed]
 
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