The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Melatonin     N-[2-(5-methoxy-1H-indol-3...

Synonyms: Circadin, Melapure, Melovine, Posidorm, Melatol, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Melatonin

 

Psychiatry related information on Melatonin

 

High impact information on Melatonin

 

Chemical compound and disease context of Melatonin

 

Biological context of Melatonin

 

Anatomical context of Melatonin

 

Associations of Melatonin with other chemical compounds

 

Gene context of Melatonin

 

Analytical, diagnostic and therapeutic context of Melatonin

References

  1. Cellular mechanisms of melatonin action. Vanecek, J. Physiol. Rev. (1998) [Pubmed]
  2. Brief report: melatonin-related hypogonadotropic hypogonadism. Puig-Domingo, M., Webb, S.M., Serrano, J., Peinado, M.A., Corcoy, R., Ruscalleda, J., Reiter, R.J., de Leiva, A. N. Engl. J. Med. (1992) [Pubmed]
  3. Diagnostic potential of melatonin analysis in pineal tumors. Miles, A., Tidmarsh, S.F., Philbrick, D., Shaw, D.M. N. Engl. J. Med. (1985) [Pubmed]
  4. Melatonin increases oestrogen receptor binding activity of human breast cancer cells. Danforth, D.N., Tamarkin, L., Lippman, M.E. Nature (1983) [Pubmed]
  5. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Toh, K.L., Jones, C.R., He, Y., Eide, E.J., Hinz, W.A., Virshup, D.M., Ptácek, L.J., Fu, Y.H. Science (2001) [Pubmed]
  6. Genetic control of melatonin synthesis in the pineal gland of the mouse. Ebihara, S., Marks, T., Hudson, D.J., Menaker, M. Science (1986) [Pubmed]
  7. Human pineal physiology and functional significance of melatonin. Macchi, M.M., Bruce, J.N. Frontiers in neuroendocrinology. (2004) [Pubmed]
  8. Improvement of sleep quality in elderly people by controlled-release melatonin. Garfinkel, D., Laudon, M., Nof, D., Zisapel, N. Lancet (1995) [Pubmed]
  9. Melatonin supersensitivity to dim light in seasonal affective disorder. McIntyre, I.M., Norman, T.R., Burrows, G.D., Armstrong, S.M. Lancet (1990) [Pubmed]
  10. Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Rubin, R.T., Heist, E.K., McGeoy, S.S., Hanada, K., Lesser, I.M. Arch. Gen. Psychiatry (1992) [Pubmed]
  11. Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Obsil, T., Ghirlando, R., Klein, D.C., Ganguly, S., Dyda, F. Cell (2001) [Pubmed]
  12. Entrainment of free-running circadian rhythms by melatonin in blind people. Sack, R.L., Brandes, R.W., Kendall, A.R., Lewy, A.J. N. Engl. J. Med. (2000) [Pubmed]
  13. Increased delta aminolevulinic acid and decreased pineal melatonin production. A common event in acute porphyria studies in the rat. Puy, H., Deybach, J.C., Bogdan, A., Callebert, J., Baumgartner, M., Voisin, P., Nordmann, Y., Touitou, Y. J. Clin. Invest. (1996) [Pubmed]
  14. Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. Kennedy, S.H., Garfinkel, P.E., Parienti, V., Costa, D., Brown, G.M. Arch. Gen. Psychiatry (1989) [Pubmed]
  15. Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity. Khalil, E.M., De Angelis, J., Ishii, M., Cole, P.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  16. Plasma melatonin and the hormone-dependency of human breast cancer. Danforth, D.N., Tamarkin, L., Mulvihill, J.J., Bagley, C.S., Lippman, M.E. J. Clin. Oncol. (1985) [Pubmed]
  17. Variable bioavailability of oral melatonin. Di, W.L., Kadva, A., Johnston, A., Silman, R. N. Engl. J. Med. (1997) [Pubmed]
  18. Melatonin is a potent modulator of dopamine release in the retina. Dubocovich, M.L. Nature (1983) [Pubmed]
  19. Putative melatonin receptors in a human biological clock. Reppert, S.M., Weaver, D.R., Rivkees, S.A., Stopa, E.G. Science (1988) [Pubmed]
  20. Extraocular circadian phototransduction in humans. Campbell, S.S., Murphy, P.J. Science (1998) [Pubmed]
  21. Disappearance of plasma melatonin after removal of a neoplastic pineal gland. Neuwelt, E.A., Lewy, A.J. N. Engl. J. Med. (1983) [Pubmed]
  22. Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans. Jones, C.R., Campbell, S.S., Zone, S.E., Cooper, F., DeSano, A., Murphy, P.J., Jones, B., Czajkowski, L., Ptácek, L.J. Nat. Med. (1999) [Pubmed]
  23. A circadian oscillator in cultured cells of chicken pineal gland. Deguchi, T. Nature (1979) [Pubmed]
  24. Absolute identification of melatonin in human plasma and cerebrospinal fluid. Smith, I., Mullen, P.E., Silman, R.E., Snedden, W., Wilson, B.W. Nature (1976) [Pubmed]
  25. Melatonin may be synthesised in enterochromaffin cells. Raikhlin, N.T., Kvetnoy, I.M., Tolkachev, V.N. Nature (1975) [Pubmed]
  26. Melatonin synthesis by the retina. Gern, W.A., Ralph, C.L. Science (1979) [Pubmed]
  27. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Simonneaux, V., Ribelayga, C. Pharmacol. Rev. (2003) [Pubmed]
  28. Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra. Balzer, I., Hardeland, R. Science (1991) [Pubmed]
  29. Light and propranolol suppress the nocturnal elevation of serotonin in the cerebrospinal fluid of rhesus monkeys. Garrick, N.A., Tamarkin, L., Taylor, P.L., Markey, S.P., Murphy, D.L. Science (1983) [Pubmed]
  30. Induction of melanized cells from a goldfish erythrophoroma: isolation of pigment translocation variants. Matsumoto, J., Lynch, T.J., Grabowski, S.M., Taylor, J.D., Tchen, T.T. Science (1982) [Pubmed]
  31. Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray. Seifman, M.A., Adamides, A.A., Nguyen, P.N., Vallance, S.A., Cooper, D.J., Kossmann, T., Rosenfeld, J.V., Morganti-Kossmann, M.C. J. Cereb. Blood Flow Metab. (2008) [Pubmed]
  32. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Coon, S.L., Roseboom, P.H., Baler, R., Weller, J.L., Namboodiri, M.A., Koonin, E.V., Klein, D.C. Science (1995) [Pubmed]
  33. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim, T.D., Kim, J.S., Kim, J.H., Myung, J., Chae, H.D., Woo, K.C., Jang, S.K., Koh, D.S., Kim, K.T. Mol. Cell. Biol. (2005) [Pubmed]
  34. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Deng, W.G., Tang, S.T., Tseng, H.P., Wu, K.K. Blood (2006) [Pubmed]
  35. Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin. del Río, B., García Pedrero, J.M., Martínez-Campa, C., Zuazua, P., Lazo, P.S., Ramos, S. J. Biol. Chem. (2004) [Pubmed]
  36. Activation of human monocytes by the pineal hormone melatonin. Morrey, K.M., McLachlan, J.A., Serkin, C.D., Bakouche, O. J. Immunol. (1994) [Pubmed]
  37. Transcriptional inhibition of oxytocin receptor expression in human myometrial cells by melatonin involves protein kinase C signaling. Sharkey, J., Olcese, J. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  38. Melatonin stimulates the release of growth hormone and prolactin by a possible induction of the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus. Chowdhury, V.S., Yamamoto, K., Saeki, I., Hasunuma, I., Shimura, T., Tsutsui, K. Endocrinology (2008) [Pubmed]
  39. A cyclic GMP-activated channel in dissociated cells of the chick pineal gland. Dryer, S.E., Henderson, D. Nature (1991) [Pubmed]
  40. Analysis of melatonin in human plasma by gas chromatography negative chemical ionization mass spectrometry. Lewy, A.J., Markey, S.P. Science (1978) [Pubmed]
  41. Daily rhythm in human urinary melatonin. Lynch, H.J., Wurtman, R.J., Moskowitz, M.A., Archer, M.C., Ho, M.H. Science (1975) [Pubmed]
 
WikiGenes - Universities