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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A new solid-phase synthesis of oligonucleotides 3'-conjugated with peptides.

A convenient 'on line' solid-phase synthesis of oligonucleotides conjugated at the 3'-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3'-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry.[1]

References

  1. A new solid-phase synthesis of oligonucleotides 3'-conjugated with peptides. De Napoli, L., Messere, A., Montesarchio, D., Piccialli, G., Benedetti, E., Bucci, E., Rossi, F. Bioorg. Med. Chem. (1999) [Pubmed]
 
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