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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Regulation of AP-1 gene transcription factor binding activity in the rat brain during nicotine dependence.

The effects of acute and chronic nicotine treatment on activator protein-1 (AP-1) gene transcription factor binding activity in the rat cortex were investigated. AP-1 DNA binding activity was determined by the electrophoretic gel mobility shift assay. It was observed that 1 h after acute nicotine treatment (single injection) AP-1 DNA binding activity was significantly increased in the rat cortex. On the other hand, AP-1 DNA binding activity in the rat cortex was not altered at 1 and 8 h of nicotine withdrawal after repeated nicotine treatment (10 days). However, at 18 and 24 h of nicotine withdrawal after 10 days of nicotine treatment, AP-1 DNA binding activity was significantly decreased in the rat cortex. Thus, these findings suggest that desensitization of cortical AP-1 DNA binding activity may be involved in the neuroadaptational mechanisms to nicotine dependence.[1]

References

  1. Regulation of AP-1 gene transcription factor binding activity in the rat brain during nicotine dependence. Pandey, S.C., Xu, T., Zhang, D. Neurosci. Lett. (1999) [Pubmed]
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