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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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5-HTTLPR variants not associated with autistic spectrum disorders.

To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders.[1]

References

  1. 5-HTTLPR variants not associated with autistic spectrum disorders. Zhong, N., Ye, L., Ju, W., Brown, W.T., Tsiouris, J., Cohen, I. Neurogenetics (1999) [Pubmed]
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