The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients.

Various investigators address an augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL), or an increased N-methylation of these compounds as putative pathophysiologic mechanisms in Parkinson's disease (PD). Objectives of this study were (1) the evaluation of a putative elevation of enantiomers (R-, S-) of SAL and (2) the investigation of relations between these metabolic precursors of neurotoxic N-methylated-SAL (NMSAL) and dopamine in cerebrospinal fluid of untreated de-novo Parkinsonian patients and age- and sex-matched healthy controls. Levels of R- and S-SAL and dopamine did not significantly (R-SAL: P = 0.75, S-SAL: P = 0.69, dopamine: P = 0.46) differ and dopamine did not correlate to R-SAL and S-SAL in both groups. We conclude, that central accumulation of R-NMSAL, which is neurotoxic to dopaminergic nigrostriatal neurons, is not due to elevated synthesis of R-SAL and/or S-SAL in PD.[1]

References

  1. R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients. Müller, T., Sällström Baum, S., Häussermann, P., Przuntek, H., Rommelspacher, H., Kuhn, W. J. Neurol. Sci. (1999) [Pubmed]
 
WikiGenes - Universities