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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pharmahuasca: human pharmacology of oral DMT plus harmine.

A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca--capsules containing crystalline N,N-dimethyltryptamine (DMT) plus harmine, as well as combinations of other psychoactive tryptamines with other beta-carbolines. The 1967 Holmstedt-Lindgren hypothesis of the ayahuasca effect--oral psychoactivity of DMT consequent to monoamine-oxidase (MAO) inhibition from simultaneous ingestion of beta-carbolines--has been confirmed by eight self-experimenters. Results of a total of some 70 bioassays are summarized and the literature on this subject is reviewed (with 66 references and one table).[1]


  1. Pharmahuasca: human pharmacology of oral DMT plus harmine. Ott, J. Journal of psychoactive drugs. (1999) [Pubmed]
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