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Gawronska-Szklarz, B. et al.

Gawronska-Szklarz, Wójcicki, Kuprianowicz, Kedzierska, Kedzierski, Górnik, Pawlik,

CYP2D6 and GSTM1 genotypes in a Polish population.

OBJECTIVE: The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population. METHODS: One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6*3 and CYP2D6*4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative). RESULTS: Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6*4 and CYP2D6*3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%. CONCLUSION: The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations.[1]

References

CYP2D6 and GSTM1 genotypes in a Polish population. Gawronska-Szklarz, B., Wójcicki, M., Kuprianowicz, A., Kedzierska, K., Kedzierski, M., Górnik, W., Pawlik, A. Eur. J. Clin. Pharmacol. (1999) [Pubmed]

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