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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD.

The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects "on" during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.[1]


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