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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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p27 expression correlates with prognosis in patients with hypopharyngeal cancer.

BACKGROUND: Hypopharyngeal cancer is closely associated with smoking, drinking, and malnutrition. Recent findings reveal that carcinogenesis depends on genetic aberrations. MATERIALS AND METHODS: Eighty-one patients with hypopharyngeal cancer were analyzed for p53, CCND1, and p27, and 72 patients were analyzed for p21, immunohistochemically. RESULTS: p53 overexpression was found in 70%, CCND1 in 17%, p21 in 29%, and p27 in 32%. The low intensity of p27 expression correlated with poor prognosis, but the level of expression of p53, CCND1, and p21 did not. CONCLUSION: The immunohistochemical analysis of p27 provides a possible tool in determining the prognosis of patients with hypopharyngeal cancer.[1]

References

  1. p27 expression correlates with prognosis in patients with hypopharyngeal cancer. Mineta, H., Miura, K., Suzuki, I., Takebayashi, S., Misawa, K., Ueda, Y., Ichimura, K. Anticancer Res. (1999) [Pubmed]
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