Gene Review:
CDKN1A - cyclin-dependent kinase inhibitor 1A (p21,...
Homo sapiens
Synonyms:
CAP20, CDK-interacting protein 1, CDKN1, CIP1, Cyclin-dependent kinase inhibitor 1, ...
De Angelis,
Kravik,
Sata,
Stokke,
Sasatomi,
Harada,
Giovannini,
Kaldis,
Hashimoto,
Murray,
Treré,
Gramantieri,
Kimura,
Cameron,
Takagi,
Hanada,
Lacchini,
Kwang S. Suh,
Luigi M. De Luca,
Kojiro,
Taniguchi,
Svendsrud,
Takemi Tanaka,
Scott,
Kawaguchi,
Koga,
Grazi,
Angela M. Lo,
Venturi,
Chieco,
Ueno,
Mirzayans,
Yano,
Bolondi,
Sakisaka,
- CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma. Kibel, A.S., Suarez, B.K., Belani, J., Oh, J., Webster, R., Brophy-Ebbers, M., Guo, C., Catalona, W.J., Picus, J., Goodfellow, P.J. Cancer Res. (2003)
- Expression Profiling of UVB Response in Melanocytes Identifies a Set of p53-Target Genes. Yang, G., Zhang, G., Pittelkow, M.R., Ramoni, M., Tsao, H. J. Invest. Dermatol. (2006)
- GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation. Gramantieri, L., Chieco, P., Giovannini, C., Lacchini, M., Treré, D., Grazi, G.L., Venturi, A., Bolondi, L. Hum. Pathol. (2005)
- Induction of stress genes by low doses of gamma rays. Amundson, S.A., Do, K.T., Fornace, A.J. Radiat. Res. (1999)
- Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone. Ohnishi, T., Ohnishi, K., Wang, X., Takahashi, A., Okaichi, K. Radiat. Res. (1999)
- The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells. Kehn, K., Deng, L., de la Fuente, C., Strouss, K., Wu, K., Maddukuri, A., Baylor, S., Rufner, R., Pumfery, A., Bottazzi, M.E., Kashanchi, F. Retrovirology (2004)
- Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease. Arendt, T., Holzer, M., Gärtner, U. Journal of neural transmission (Vienna, Austria : 1996) (1998)
- Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. Strait, K.A., Dabbas, B., Hammond, E.H., Warnick, C.T., Iistrup, S.J., Ford, C.D. Mol. Cancer Ther. (2002)
- Another Piece of the p27(Kip1) Puzzle. Kaldis, P. Cell (2007)
- Telomeres, p21 and the cancer-aging hypothesis. Bell, J.F., Sharpless, N.E. Nat. Genet. (2007)
- Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Choudhury, A.R., Ju, Z., Djojosubroto, M.W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., Lee, H.W., von Zglinicki, T., Ganser, A., Schirmacher, P., Nakauchi, H., Rudolph, K.L. Nat. Genet. (2007)
- Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Cariou, S., Donovan, J.C., Flanagan, W.M., Milic, A., Bhattacharya, N., Slingerland, J.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. Mitsuuchi, Y., Johnson, S.W., Selvakumaran, M., Williams, S.J., Hamilton, T.C., Testa, J.R. Cancer Res. (2000)
- Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. Koga, H., Sakisaka, S., Harada, M., Takagi, T., Hanada, S., Taniguchi, E., Kawaguchi, T., Sasatomi, K., Kimura, R., Hashimoto, O., Ueno, T., Yano, H., Kojiro, M., Sata, M. Hepatology (2001)
- Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. Yang, E.S., Burnstein, K.L. J. Biol. Chem. (2003)
- Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells. Qiu, X., Forman, H.J., Schönthal, A.H., Cadenas, E. J. Biol. Chem. (1996)
- Factors underlying the cell growth-related bystander responses to alpha particles. Iyer, R., Lehnert, B.E., Svensson, R. Cancer Res. (2000)
- p21/CDKN1A mediates negative regulation of transcription by p53. Löhr, K., Möritz, C., Contente, A., Dobbelstein, M. J. Biol. Chem. (2003)
- Cell cycle regulation of the T-box transcription factor tbx2. Bilican, B., Goding, C.R. Exp. Cell Res. (2006)
- Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53. Mirzayans, R., Scott, A., Cameron, M., Murray, D. Radiat. Res. (2005)
- Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair. Jakob, B., Scholz, M., Taucher-Scholz, G. Int. J. Radiat. Biol. (2002)
- p21+/+ (CDKN1A+/+) and p21-/- (CDKN1A-/-) human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. Larsson, C., Ng, C.E. Radiat. Res. (2003)
- Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Azzam, E.I., de Toledo, S.M., Gooding, T., Little, J.B. Radiat. Res. (1998)
- Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. De Angelis, P.M., Svendsrud, D.H., Kravik, K.L., Stokke, T. Mol. Cancer (2006)
- Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Zhao, Y., Lu, S., Wu, L., Chai, G., Wang, H., Chen, Y., Sun, J., Yu, Y., Zhou, W., Zheng, Q., Wu, M., Otterson, G.A., Zhu, W.G. Mol. Cell. Biol. (2006)
- p21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer. Tanaka, T., Suh, K.S., Lo, A.M., De Luca, L.M. J. Biol. Chem. (2007)
- Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M., Kuriyan, J. Cell (1996)
- Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity. Dash, B.C., El-Deiry, W.S. Mol. Cell. Biol. (2005)
- G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Akiyama, T., Yoshida, T., Tsujita, T., Shimizu, M., Mizukami, T., Okabe, M., Akinaga, S. Cancer Res. (1997)
- Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. Koutsodontis, G., Tentes, I., Papakosta, P., Moustakas, A., Kardassis, D. J. Biol. Chem. (2001)
- P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Soria, G., Podhajcer, O., Prives, C., Gottifredi, V. Oncogene (2006)
- Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation. Witko-Sarsat, V., Canteloup, S., Durant, S., Desdouets, C., Chabernaud, R., Lemarchand, P., Descamps-Latscha, B. J. Biol. Chem. (2002)
- Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Zhang, Y., Fujita, N., Tsuruo, T. Oncogene (1999)
- Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. Park, J.A., Kim, K.W., Kim, S.I., Lee, S.K. Eur. J. Biochem. (1998)
- In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repair. Gramantieri, L., Trerè, D., Chieco, P., Lacchini, M., Giovannini, C., Piscaglia, F., Cavallari, A., Bolondi, L. J. Hepatol. (2003)
- The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Waga, S., Hannon, G.J., Beach, D., Stillman, B. Nature (1994)
- p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Saha, P., Eichbaum, Q., Silberman, E.D., Mayer, B.J., Dutta, A. Mol. Cell. Biol. (1997)
- p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Fritah, A., Saucier, C., Mester, J., Redeuilh, G., Sabbah, M. Mol. Cell. Biol. (2005)
- RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Shu, L., Yan, W., Chen, X. Genes Dev. (2006)
- A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. Rohaly, G., Chemnitz, J., Dehde, S., Nunez, A.M., Heukeshoven, J., Deppert, W., Dornreiter, I. Cell (2005)
- Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. Fan, Z., Lu, Y., Wu, X., DeBlasio, A., Koff, A., Mendelsohn, J. J. Cell Biol. (1995)
- Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Alcorta, D.A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., Barrett, J.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity. Kriwacki, R.W., Hengst, L., Tennant, L., Reed, S.I., Wright, P.E. Proc. Natl. Acad. Sci. U.S.A. (1996)
- PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano, M., Dutta, A. Genes Dev. (2008)
- Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. Bani, M.R., Nicoletti, M.I., Alkharouf, N.W., Ghilardi, C., Petersen, D., Erba, E., Sausville, E.A., Liu, E.T., Giavazzi, R. Mol. Cancer Ther. (2004)