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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Isolation of 10-hydroxycoronaridine from Tabernaemontana penduliflora and its estrogen-like activity.

The methanol extract of Tabernaemontana penduliflora was found to appreciably inhibit [3H]-estradiol binding to estrogen receptors. Activity-guided fractionation led to the isolation of two known alkaloids, 10-hydroxycoronaridine (1) and its 10-O-methyl ether, voacangine (2). These alkaloids together with other related alkaloids were tested for their estrogenic activities. Among these molecules, 1 was found to be the most potent estrogen agonist and is distinctly more active than genistein.[1]

References

  1. Isolation of 10-hydroxycoronaridine from Tabernaemontana penduliflora and its estrogen-like activity. Masuda, K., Akiyama, T., Taki, M., Takaishi, S., Iijima, Y., Yamazaki, M., Aimi, N., Jato, J., Waterman, P.G. Planta Med. (2000) [Pubmed]
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