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Chemical Compound Review

MOLI000995     methanol

Synonyms: AC1L9OZ4
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Disease relevance of methanol


Psychiatry related information on methanol


High impact information on methanol

  • With methanol-acetone fixation, required for the antibody reaction, the characteristically long mitochondria of human skin fibroblasts fragment into strings of beads, as identified by antibody staining in the light microscope and whole-mount electron microscopy [11].
  • However, these membranes require humid operating conditions, which limit the temperature of operation to less than 100 degrees C; they are also permeable to methanol and hydrogen, which lowers fuel efficiency [12].
  • Initial biochemical characterization of the target epitope reveals that it is a lipid present in chloroform/methanol extracts from perinatal retina and is sensitive to neuraminidase digestion [13].
  • Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism converts more growth substrate, methanol, into cellular carbon [2].
  • Prominent examples of flexibility are the use in denitrification of nitrate, nitrite, nitrous oxide, and nitric oxide as alternative electron acceptors to oxygen and the ability to use C1 compounds (e.g., methanol and methylamine) as electron donors to the respiratory chains [14].

Chemical compound and disease context of methanol


Biological context of methanol


Anatomical context of methanol


Associations of methanol with other chemical compounds


Gene context of methanol

  • Evidence of ongoing proliferative activity was documented in all 7 methanol-preserved specimens: 24.6+/-2.3% of SMCs were PCNA-positive, 24.8+/-3.1% were cyclin E-positive, and 22.5+/-2.2% were cdk2-positive [35].
  • PMP2 encodes a 43-amino acid polypeptide that can be extracted from the membrane with chloroform/methanol [36].
  • After induction with methanol, the medium contained approx, 40 and 400 mg/l of soluble recombinant Kre2p/Mnt1p and Ktr1p respectively [37].
  • For MRP recognized by MRPm6, the optimal fixation condition was acetone for 5 min at room temperature in immunocytochemistry, and methanol for 15 min at -20 degrees C in flow cytometry [38].
  • The relationship among protein oligomerization, secondary structure at the interface, and the interfacial behavior was investigated for spread layers of native pulmonary surfactant associated proteins B and C. SP-B and SP-C were isolated either from butanol or chloroform/methanol lipid extracts that were obtained from sheep lung washings [39].

Analytical, diagnostic and therapeutic context of methanol


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  3. The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes. Blondin, J., Janoff, A. J. Clin. Invest. (1976) [Pubmed]
  4. Prevention of tumor growth after intradermal injection of BCG extracts: a comparison of results in strain-2 guinea pigs from the National Institutes of Health and from the National Jewish Hospital and Research Center. Zbar, B., Minden, P., McClatchy, J.K., Rapp, H.J. J. Natl. Cancer Inst. (1976) [Pubmed]
  5. Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. Park, I.W., Wistuba, I.I., Maitra, A., Milchgrub, S., Virmani, A.K., Minna, J.D., Gazdar, A.F. J. Natl. Cancer Inst. (1999) [Pubmed]
  6. Preparation of deacetyl-, lyso-, and deacetyl-lyso-GM(3) by selective alkaline hydrolysis of GM3 ganglioside. Valiente, O., Mauri, L., Casellato, R., Fernandez, L.E., Sonnino, S. J. Lipid Res. (2001) [Pubmed]
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  11. Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts. Mose-Larsen, P., Bravo, R., Fey, S.J., Small, J.V., Celis, J.E. Cell (1982) [Pubmed]
  12. Solid acids as fuel cell electrolytes. Haile, S.M., Boysen, D.A., Chisholm, C.R., Merle, R.B. Nature (2001) [Pubmed]
  13. A cell surface molecule distributed in a dorsoventral gradient in the perinatal rat retina. Constantine-Paton, M., Blum, A.S., Mendez-Otero, R., Barnstable, C.J. Nature (1986) [Pubmed]
  14. Molecular genetics of the genus Paracoccus: metabolically versatile bacteria with bioenergetic flexibility. Baker, S.C., Ferguson, S.J., Ludwig, B., Page, M.D., Richter, O.M., van Spanning, R.J. Microbiol. Mol. Biol. Rev. (1998) [Pubmed]
  15. Effect of Corynebacterium parvum, methanol-extraction residue of BCG, and levamisole on macrophage random migration, chemotaxis, and pinocytosis. Sher, N.A., Poplack, D.G., Blaese, R.M., Brown, T.M., Chaparas, S.D. J. Natl. Cancer Inst. (1977) [Pubmed]
  16. Combined formate and lactate acidosis in methanol poisoning. Smith, S.R., Smith, S.J., Buckley, B.M. Lancet (1981) [Pubmed]
  17. Discrete length classes of DNA depend on mode of dehydration. Vollenweider, H.J., James, A., Szybalski, W. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  18. Role of hepatic tetrahydrofolate in the species difference in methanol toxicity. Black, K.A., Eells, J.T., Noker, P.E., Hawtrey, C.A., Tephly, T.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  19. Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatoma. Munger, C., Ellis, A., Woods, K., Randolph, J., Yanovich, S., Gewirtz, D. Cancer Res. (1988) [Pubmed]
  20. Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. Sajjan, U.S., Corey, M., Karmali, M.A., Forstner, J.F. J. Clin. Invest. (1992) [Pubmed]
  21. In vitro induction of cell-mediated immunity to murine leukemia cells. III. Effect of methanol extraction residue fraction of BCG on the generation of cytotoxic lymphocytes against leukemia. Kedar, E., Nahas, F., Unger, E., Weiss, D.W. J. Natl. Cancer Inst. (1978) [Pubmed]
  22. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. Steen, R.L., Cubizolles, F., Le Guellec, K., Collas, P. J. Cell Biol. (2000) [Pubmed]
  23. Effect of various hepatic membrane fractions on microtubule assembly-with special emphasis on the role of membrane phospholipids. Reaven, E., Azhar, S. J. Cell Biol. (1981) [Pubmed]
  24. Ankyrin is fatty acid acylated in erythrocytes. Staufenbiel, M., Lazarides, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers. Prokopczyk, B., Cox, J.E., Hoffmann, D., Waggoner, S.E. J. Natl. Cancer Inst. (1997) [Pubmed]
  26. The absence of Pmp47, a putative yeast peroxisomal transporter, causes a defect in transport and folding of a specific matrix enzyme. Sakai, Y., Saiganji, A., Yurimoto, H., Takabe, K., Saiki, H., Kato, N. J. Cell Biol. (1996) [Pubmed]
  27. Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. Toschi, L., Bravo, R. J. Cell Biol. (1988) [Pubmed]
  28. Synthesis and subcellular location of peroxisomal membrane proteins in a peroxisome-deficient mutant of the yeast Hansenula polymorpha. Sulter, G.J., Vrieling, E.G., Harder, W., Veenhuis, M. EMBO J. (1993) [Pubmed]
  29. Striated microtubule-associated fibers: identification of assemblin, a novel 34-kD protein that forms paracrystals of 2-nm filaments in vitro. Lechtreck, K.F., Melkonian, M. J. Cell Biol. (1991) [Pubmed]
  30. Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney. Chambers, S.T., Kunin, C.M. J. Clin. Invest. (1987) [Pubmed]
  31. In vitro and in vivo formation of 7-(2'-carboxyethyl)guanine from the liver carcinogen 1-nitroso-5,6-dihydrouracil and its reactions with water and methanol. Mirvish, S.S., Ross, A.E., Gold, B., Drake, N. J. Natl. Cancer Inst. (1985) [Pubmed]
  32. The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. Tan, X., Waterham, H.R., Veenhuis, M., Cregg, J.M. J. Cell Biol. (1995) [Pubmed]
  33. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. Koller, A., Snyder, W.B., Faber, K.N., Wenzel, T.J., Rangell, L., Keller, G.A., Subramani, S. J. Cell Biol. (1999) [Pubmed]
  34. Serum formate concentrations in methanol intoxication as a criterion for hemodialysis. Osterloh, J.D., Pond, S.M., Grady, S., Becker, C.E. Ann. Intern. Med. (1986) [Pubmed]
  35. Histopathology of in-stent restenosis in patients with peripheral artery disease. Kearney, M., Pieczek, A., Haley, L., Losordo, D.W., Andres, V., Schainfeld, R., Rosenfield, K., Isner, J.M. Circulation (1997) [Pubmed]
  36. Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. Navarre, C., Catty, P., Leterme, S., Dietrich, F., Goffeau, A. J. Biol. Chem. (1994) [Pubmed]
  37. Ktr1p is an alpha-1,2-mannosyltransferase of Saccharomyces cerevisiae. Comparison of the enzymic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris. Romero, P.A., Lussier, M., Sdicu, A.M., Bussey, H., Herscovics, A. Biochem. J. (1997) [Pubmed]
  38. Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia. Den Boer, M.L., Zwaan, C.M., Pieters, R., Kazemier, K.M., Rottier, M.M., Flens, M.J., Scheper, R.J., Veerman, A.J. Leukemia (1997) [Pubmed]
  39. Effects of oligomerization and secondary structure on the surface behavior of pulmonary surfactant proteins SP-B and SP-C. Wüstneck, N., Wüstneck, R., Perez-Gil, J., Pison, U. Biophys. J. (2003) [Pubmed]
  40. Production of chemotactic activity for polymorphonuclear leukocytes by cultured rat hepatocytes exposed to ethanol. Perez, H.D., Roll, F.J., Bissell, D.M., Shak, S., Goldstein, I.M. J. Clin. Invest. (1984) [Pubmed]
  41. Effect of immunotherapy with Corynebacterium parvum and methanol extraction residue of BCG administered intravenously on host defense function in cancer patients. Hersh, E.M., Murphy, S.G., Quesada, J.R., Gutterman, J.U., Gschwind, C.R., Morgan, J. J. Natl. Cancer Inst. (1981) [Pubmed]
  42. Endogenous glycosyltransferases glucosylate lipids in flagella of Euglena. Chen, S.J., Bouck, G.B. J. Cell Biol. (1984) [Pubmed]
  43. Cardiolipin is a normal component of human plasma lipoproteins. Deguchi, H., Fernandez, J.A., Hackeng, T.M., Banka, C.L., Griffin, J.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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