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Le Mellédo, J.M. et al.

Le Mellédo, Van Driel, Coupland, Lott, Jhangri,

Response to flumazenil in women with premenstrual dysphoric disorder.

OBJECTIVE: The authors sought to determine whether the administration of flumazenil would induce marked panic symptoms in women suffering from premenstrual dysphoric disorder. METHOD: Ten women with premenstrual dysphoric disorder and 11 comparison subjects were injected with flumazenil or placebo in a double-blind, randomized, balanced crossover design in a single session in the luteal phase of their menstrual cycles. RESULTS: Flumazenil induced a much greater panic response in the women with premenstrual dysphoric disorder than in the comparison subjects. CONCLUSIONS: These preliminary results are consistent with a dysregulation of the g-aminobutyric acid A/benzodiazepine receptor complex during the premenstruum of women suffering from premenstrual dysphoric disorder.[1]

References

Response to flumazenil in women with premenstrual dysphoric disorder. Le Mellédo, J.M., Van Driel, M., Coupland, N.J., Lott, P., Jhangri, G.S. The American journal of psychiatry. (2000) [Pubmed]

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