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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.

Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 ( CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration.[1]

References

  1. Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers. DeVane, C.L., Markowitz, J.S., Carson, S.W., Boulton, D.W., Gill, H.S., Nahas, Z., Risch, S.C. Journal of clinical psychopharmacology. (2000) [Pubmed]
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