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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cerebrospinal fluid pressure during O2 encephalography and N2O inhalation.

Cerebrospinal fluid (CSF) pressure was studied in 8 patients and 5 dogs during pneumoencephalography (PEG) or ventriculography in which either O2 or N2O was used as the contrast gas prior to and during N2O inhalation. In 7 patients, the use of O2 as the contrast gas increased CSF pressure 8.7 torr (range 4 to 12 torr) following N2O inhalation. In 1 patient, when N2O was used as the contrast gas, CSF pressure did not change after N2O inhalation. These findings were confirmed in anesthetized animals ventilated at a constant PaCO2. The authors conclude that if N2O inhalation is required during PEG, maximum patient safety can be achieved if the contrast gas is also N2O.[1]


  1. Cerebrospinal fluid pressure during O2 encephalography and N2O inhalation. Paul, W.L., Munson, E.S., Maniscalco, J.E. Anesth. Analg. (1976) [Pubmed]
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