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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Gabapentin is effective in treating nocturnal painful spasms in multiple sclerosis.

In-patients with MS nocturnal spasms ( NPS) occur frequently, primarily during the night and may influence the ability to and/or quality of sleep. We enrolled in an open label trial with GBP (up to 600 mg/day) 24 MS patients with NPS. We obtained patient reports of subjective discomfort at pre-treatment and following 2- (T1) and 8 weeks (T2), utilizing a 3-point analogue scale. Twenty of the 22 patients who completed the study reported resolution or amelioration of discomfort. Clinical improvement occurred 1 - 5 days following initial treatment. Three patients experienced adverse effects but completed the minimal follow-up period (2 weeks). Two patient dropped out of the study due to no compliance or adverse effects. A very low dose of GBP may be effective treatment for MS patients with NPS who may benefit from rapid improvement of discomfort with minimal risk of adverse effects.[1]

References

  1. Gabapentin is effective in treating nocturnal painful spasms in multiple sclerosis. Solaro, C., Uccelli, M.M., Guglieri, P., Uccelli, A., Mancardi, G.L. Mult. Scler. (2000) [Pubmed]
 
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