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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hermecz, I. et al.

Hermecz, Kánai,

Prolyl endopeptidase inhibitors.

Selective prolyl endopeptidase inhibitors were elaborated by modification of the structure of SUAM-1221, by using a CoMFA study and protein crystallography. The most active representatives of omega-(N-hetaryl)alkanoylprolylpyrrolidines, containing 2- or 3-methylene chain links have high activity (IC50 10(-9)-10(-11)) and exhibit significant in vivo activities.[1]

References

Prolyl endopeptidase inhibitors. Hermecz, I., Kánai, K. Farmaco (2000) [Pubmed]

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