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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dynamics of lip dyskinesia associated with neuroleptic withdrawal.

The lip movements associated with dyskinesia in adults with mental retardation were investigated through a dynamic analysis at medication baseline, at the points of the highest level of withdrawal dyskinesia as indexed by the DISCUS rating scale, and at the lowest level of dyskinesia following complete withdrawal of the medication. Results showed that the changes in the amount of lip oscillations following medication reduction and eventual withdrawal were strongly linked to changes in the structural complexity of the dynamics of lip motions. These findings provide evidence that neuroleptic medication reduces the df of the dynamics of the movement output and that this change is inversely related to the level of tardive dyskinetic motion observed in the clinical setting.[1]


  1. Dynamics of lip dyskinesia associated with neuroleptic withdrawal. Newell, K.M., Bodfish, J.W., Mahorney, S.L., Sprague, R.L. American journal of mental retardation : AJMR. (2000) [Pubmed]
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