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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Aquaporin 4: lack of mRNA expression in the rat regenerating muscle fiber under denervation.

The recently identified water channel aquaporin 4 is a major component of the orthogonal arrays observed with freeze-fracture electron microscopy. We examined the expression of aquaporin 4 mRNA and protein in rat regenerating muscle under innervated and denervated conditions. We found decreased sarcolemmal immunostaining of aquaporin 4 in denervated regenerating muscle as opposed to innervated muscle. Quantitative reverse transcription-polymerase chain reaction revealed that aquaporin 4 mRNA was expressed in the innervated regenerating muscle; whereas it was not expressed in denervated muscle. Thus, lack of aquaporin 4 protein may be due to lack of aquaporin 4 mRNA in the denervated regenerating muscle. We conclude that the nerve supply influences expression of aquaporin 4 at the mRNA level in regenerating muscle.[1]


  1. Aquaporin 4: lack of mRNA expression in the rat regenerating muscle fiber under denervation. Jimi, T., Wakayama, Y., Murahashi, M., Shibuya, S., Inoue, M., Hara, H., Matsuzaki, Y., Uemura, N. Neurosci. Lett. (2000) [Pubmed]
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