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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Denervation


Psychiatry related information on Denervation


High impact information on Denervation


Chemical compound and disease context of Denervation


Biological context of Denervation


Anatomical context of Denervation


Associations of Denervation with chemical compounds

  • Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation [30].
  • These observations suggest that an increase in alphaadrenergic receptor numbers may account for the denervation supersensitivity to infused norepinephrine in patients with sympathetic degeneration [31].
  • Consistent with this concept, we show here that selective sensory-fiber denervation with capsaicin and targeted deletion of the PPT-A gene protect murine lungs against both immune complex-mediated and stretch-mediated injuries [32].
  • The enhancement of ileal glucose absorption was half-maximal in 40-45 d, could be reversed by 10 d of treatment with insulin and did not result from adrenergic denervation [33].
  • Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats [34].

Gene context of Denervation

  • Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87 [35].
  • Four AML1 transcripts are expressed in denervated muscle, and the abundance of each transcript increases after denervation [36].
  • Natural history of denervation in SMA: relation to age, SMN2 copy number, and function [37].
  • The comparable response to leptin under intravenous or intracerebroventricular infusion and the loss of responsiveness after denervation strongly suggest that the acute effects of leptin involve central signaling pathways [38].
  • In conclusion, our observations strongly indicate that myenteric denervation in acute-phase T. cruzi infection is because of IFN-gamma-elicited NO production resulting from iNOS activation in the inflammatory foci along the intestinal wall [39].

Analytical, diagnostic and therapeutic context of Denervation


  1. Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. Scherrer, U., Vissing, S.F., Morgan, B.J., Rollins, J.A., Tindall, R.S., Ring, S., Hanson, P., Mohanty, P.K., Victor, R.G. N. Engl. J. Med. (1990) [Pubmed]
  2. Sprouting of synapses after partial denervation of frag cardic ganglion. Courtney, K., Roper, S. Nature (1976) [Pubmed]
  3. Serotonergic denervation partially protects rat striatum from kainic acid toxicity. Berger, M., Sperk, G., Hornykiewicz, O. Nature (1982) [Pubmed]
  4. Regulation of glucose homeostasis in humans with denervated livers. Perseghin, G., Regalia, E., Battezzati, A., Vergani, S., Pulvirenti, A., Terruzzi, I., Baratti, D., Bozzetti, F., Mazzaferro, V., Luzi, L. J. Clin. Invest. (1997) [Pubmed]
  5. Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Chang, E.B., Fedorak, R.N., Field, M. Gastroenterology (1986) [Pubmed]
  6. Inappropriate sexual behavior and denervation supersensitivity of limbic and midbrain LHRH receptors in Tourette's syndrome. Sandyk, R., Kwo-on-Yuen, P.F., Awerbuch, G., Bamford, C.R. Journal of clinical psychopharmacology. (1988) [Pubmed]
  7. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Tong, X.K., Hamel, E. Neuroscience (1999) [Pubmed]
  8. Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease. Sundström, E., Fredriksson, A., Archer, T. Brain Res. (1990) [Pubmed]
  9. D1 dopamine receptor-mediated substance P depletion in the striatonigral neurons of rats subjected to neonatal dopaminergic denervation: implications for self-injurious behavior. Sivam, S.P. Brain Res. (1989) [Pubmed]
  10. The role of positron emission tomography imaging in movement disorders. Bohnen, N.I., Frey, K.A. Neuroimaging Clin. N. Am. (2003) [Pubmed]
  11. Late denervation in patients with antecedent paralytic poliomyelitis. Cashman, N.R., Maselli, R., Wollmann, R.L., Roos, R., Simon, R., Antel, J.P. N. Engl. J. Med. (1987) [Pubmed]
  12. Dopaminergic D-3 binding sites are not presynaptic autoreceptors. Leff, S.E., Creese, I. Nature (1983) [Pubmed]
  13. Denervation of newborn rat muscle does not block the appearance of adult fast myosin heavy chain. Butler-Browne, G.S., Bugaisky, L.B., Cuénoud, S., Schwartz, K., Whalen, R.G. Nature (1982) [Pubmed]
  14. Denervation supersensitivity in the striatonigral GABA pathway. Waddington, J.L., Cross, A.J. Nature (1978) [Pubmed]
  15. Effect of denervation and local damage on extrajunctional L-glutamate receptors in locust muscle. Cull-Candy, S.G. Nature (1975) [Pubmed]
  16. Treatment of tardive dyskinesia with bromocriptine. A test of the receptor modification strategy. Lieberman, J.A., Alvir, J., Mukherjee, S., Kane, J.M. Arch. Gen. Psychiatry (1989) [Pubmed]
  17. Adrenergic effects on reentrant ventricular rhythms in subacute myocardial infarction. Butrous, G.S., Gough, W.B., Restivo, M., Yang, H., el-Sherif, N. Circulation (1992) [Pubmed]
  18. Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application. Minardo, J.D., Tuli, M.M., Mock, B.H., Weiner, R.E., Pride, H.P., Wellman, H.N., Zipes, D.P. Circulation (1988) [Pubmed]
  19. Distribution of left ventricular sympathetic afferents demonstrated by reflex responses to transmural myocardial ischemia and to intracoronary and epicardial bradykinin. Minisi, A.J., Thames, M.D. Circulation (1993) [Pubmed]
  20. Role of renal nerves, angiotensin II, and prostaglandins in the antinatriuretic response to acute hypercapnic acidosis in the dog. Anderson, R.J., Henrich, W.L., Gross, P.A., Dillingham, M.A. Circ. Res. (1982) [Pubmed]
  21. Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla. LaGamma, E.F., Adler, J.E., Black, I.B. Science (1984) [Pubmed]
  22. Mechanism of postarrhythmic renal vasoconstriction in the anesthetized dog. Katholi, R.E., Oparil, S., Urthaler, F., James, T.N. J. Clin. Invest. (1979) [Pubmed]
  23. Neural regulation of muscle acetylcholine receptor epsilon- and alpha-subunit gene promoters in transgenic mice. Gundersen, K., Sanes, J.R., Merlie, J.P. J. Cell Biol. (1993) [Pubmed]
  24. Myogenin and MyoD join a family of skeletal muscle genes regulated by electrical activity. Eftimie, R., Brenner, H.R., Buonanno, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  25. Cholinergic mechanism in the large cat cerebral artery. Lee, T.J. Circ. Res. (1982) [Pubmed]
  26. Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels. Ogawa, S., Barnett, J.V., Sen, L., Galper, J.B., Smith, T.W., Marsh, J.D. J. Clin. Invest. (1992) [Pubmed]
  27. Expression of 5-HT3 receptors in the rat gastrointestinal tract. Glatzle, J., Sternini, C., Robin, C., Zittel, T.T., Wong, H., Reeve, J.R., Raybould, H.E. Gastroenterology (2002) [Pubmed]
  28. Myenteric plexus destruction alters morphology of rat intestine. Hadzijahic, N., Renehan, W.E., Ma, C.K., Zhang, X., Fogel, R. Gastroenterology (1993) [Pubmed]
  29. Skeletal muscle denervation activates acetylcholine receptor genes. Tsay, H.J., Schmidt, J. J. Cell Biol. (1989) [Pubmed]
  30. Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction. Levitt, T.A., Loring, R.H., Salpeter, M.M. Science (1980) [Pubmed]
  31. Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man. Davies, B., Sudera, D., Sagnella, G., Marchesi-Saviotti, E., Mathias, C., Bannister, R., Sever, P. J. Clin. Invest. (1982) [Pubmed]
  32. Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation. Chavolla-Calderón, M., Bayer, M.K., Fontán, J.J. J. Clin. Invest. (2003) [Pubmed]
  33. Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats. Fedorak, R.N., Chang, E.B., Madara, J.L., Field, M. J. Clin. Invest. (1987) [Pubmed]
  34. Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats. Tucker, B.J., Mundy, C.A., Maciejewski, A.R., Printz, M.P., Ziegler, M.G., Pelayo, J.C., Blantz, R.C. J. Clin. Invest. (1986) [Pubmed]
  35. Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87. Blagden, C.S., Fromm, L., Burden, S.J. Mol. Cell. Biol. (2004) [Pubmed]
  36. AML1 is expressed in skeletal muscle and is regulated by innervation. Zhu, X., Yeadon, J.E., Burden, S.J. Mol. Cell. Biol. (1994) [Pubmed]
  37. Natural history of denervation in SMA: relation to age, SMN2 copy number, and function. Swoboda, K.J., Prior, T.W., Scott, C.B., McNaught, T.P., Wride, M.C., Reyna, S.P., Bromberg, M.B. Ann. Neurol. (2005) [Pubmed]
  38. Downregulation of uncoupling protein 2 mRNA in white adipose tissue and uncoupling protein 3 mRNA in skeletal muscle during the early stages of leptin treatment. Combatsiaris, T.P., Charron, M.J. Diabetes (1999) [Pubmed]
  39. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Arantes, R.M., Marche, H.H., Bahia, M.T., Cunha, F.Q., Rossi, M.A., Silva, J.S. Am. J. Pathol. (2004) [Pubmed]
  40. Tetrahydrobiopterin increases in adrenal medulla and cortex: a factor in the regulation of tyrosine hydroxylase. Abou-Donia, M.M., Viveros, O.H. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  41. Contractions of canine vascular smooth muscle cells caused by ouabain are due to release of norepinephrine from adrenergic nerve endings. Aarhus, L.L., Shepherd, J.T., Tyce, G.M., Verbeuren, T.J., Vanhoutte, P.M. Circ. Res. (1983) [Pubmed]
  42. Time course of denervation of efferent sympathetic and vagal nerves after occlusion of the coronary artery in the canine heart. Inoue, H., Zipes, D.P. Circ. Res. (1988) [Pubmed]
  43. Vagotomy-induced enhancement of mechanical hyperalgesia in the rat is sympathoadrenal-mediated. Khasar, S.G., Miao, F.J., Jänig, W., Levine, J.D. J. Neurosci. (1998) [Pubmed]
  44. Dopamine denervation does not alter in vivo 3H-spiperone binding in rat striatum: implications for external imaging of dopamine receptors in Parkinson's disease. Bennett, J.P., Wooten, G.F. Ann. Neurol. (1986) [Pubmed]
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