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Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation.

Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.[1]

References

  1. Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation. Lim, S.S., Jung, S.H., Ji, J., Shin, K.H., Keum, S.R. Chem. Pharm. Bull. (2000) [Pubmed]
 
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