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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene.

Interferon regulatory factors constitute a family of transcriptional activators and repressors involved in a large number of vital cellular processes. Interferon regulatory factor-3 (IRF-3) has been implicated in virus and double-stranded RNA mediated induction of IFNbeta and RANTES, in DNA damage signaling, and in virus-induced apoptosis. With its critical role in these pathways, the activity of IRF-3 is tightly regulated in myriad ways. Here we describe novel regulation of IRF-3 at the level of RNA splicing. We show that an unprecedented dual utilization of a splice acceptor/donor site within the IRF-3 mRNA governs the production of two alternative splice isoforms.[1]

References

  1. Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene. Karpova, A.Y., Howley, P.M., Ronco, L.V. Genes Dev. (2000) [Pubmed]
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