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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.

Both saturated (SFA) and unsaturated fatty acids ( UFS) inhibited PHA- and PPD-induced lymphocyte transformation. The degree of inhibition varied with the nature of the fatty acid (FA) and further comparison with their effect on unstimulated lymphocyte cultures suggests a specific action of polyunsaturated fatty acid (PUFA) on the lymphocyte PHA- and -PPD interaction. These findings are briefly discussed in the light of similar observations with PUFA-derived prostaglandins.[1]

References

  1. Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD. Mertin, J., Hughes, D. Int. Arch. Allergy Appl. Immunol. (1975) [Pubmed]
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