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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.

Both saturated (SFA) and unsaturated fatty acids ( UFS) inhibited PHA- and PPD-induced lymphocyte transformation. The degree of inhibition varied with the nature of the fatty acid (FA) and further comparison with their effect on unstimulated lymphocyte cultures suggests a specific action of polyunsaturated fatty acid (PUFA) on the lymphocyte PHA- and -PPD interaction. These findings are briefly discussed in the light of similar observations with PUFA-derived prostaglandins.[1]


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