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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The excretion of 2-hydroxyestrone during the menstrual cycle.

A double isotope derivative determination technique was developed to investigate the excretion of 2-hydroxyestrone inhuman menstrual cycle. The method is highly specific, accurate and precise within the range of 0.2-20 nmol 2-hydroxyestrone/20ml of urine. The amounts of 2-hydroxyestrone excreted during menstrual cycle varied between 10 (proliferation phase) and 60 mug/24 h urine (ovulatory peak), which is comparable to that of estriol, supposed hitherto to be the main excretion product of estrogen metabolism.[1]


  1. The excretion of 2-hydroxyestrone during the menstrual cycle. Ball, P., Gelbke, H.P., Knuppen, R. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
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